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Elucidando el ordenamiento en el autoensamblado glicocálix imitando los copolímeros supramoleculares en el agua
Simone I S Hendrikse1, Lu Su1, Tim P Hogervorst2
1Institute for Complex Molecular Systems , Eindhoven University of Technology , P.O. Box 513, 5600 MB Eindhoven , The Netherlands.
Journal of the American Chemical Society
|August 8, 2019
Resumen
Los nuevos monómeros de benceno-1,3,5-tricarboxamida (BTA) con adherencias de carbohidratos permiten el control del ensamblaje supramolecular. Esto permite la creación de biomateriales funcionales como fibras 1D e hidrogeles con propiedades ajustables.
Área de la Ciencia:
- Química supramolecular
- Ciencias de los biomateriales
- Química de los carbohidratos
Sus antecedentes:
- Los polisacáridos son vitales para las funciones biológicas y el desarrollo de biomateriales.
- La funcionalización espacial de los polisacáridos en los biomateriales es un desafío.
- Los monómeros supramoleculares basados en el benceno-1,3,5-tricarboxamida (BTA) ofrecen una plataforma para la funcionalización.
Objetivo del estudio:
- Diseñar y sintetizar nuevos monómeros de BTA glucosilados.
- Investigar la influencia de los apéndices de carbohidratos en el ensamblaje supramolecular.
- Desarrollar biomateriales funcionales con propiedades ajustables.
Principales métodos:
- Síntesis de monómeros de BTA con mono y disacáridos.
- Caracterización del comportamiento de ensamblaje supramolecular (fibras 1D, micelas).
- Copolimización de monómeros de BTA para controlar la densidad y las propiedades de los sacarídeos.
Principales resultados:
- La naturaleza de los carbohidratos dicta la polimerización supramolecular.
- BTA-Glc y BTA-Man forman fibras helicoidales 1D; BTA-Cel y BTA-OEG4-Man forman micelas.
- La copolimerización produce fibras 1D con contenido ajustable de sacáridos y intercambio dinámico.
Conclusiones:
- Los monómeros de BTA glicosilados proporcionan control sobre el autoensamblaje.
- Se puede lograr una densidad ajustable de sacaridos en las fibras 1D.
- Se permite el desarrollo de biomateriales funcionales, incluidos los hidrogeles sintonizables.
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