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Videos de Conceptos Relacionados

Pharmacogenetics and Pharmacogenomics: Overview01:29

Pharmacogenetics and Pharmacogenomics: Overview

Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...
Principles of Pharmacogenetics: Types of Genetic Variants01:27

Principles of Pharmacogenetics: Types of Genetic Variants

The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
Pharmacogenetics of Drug Metabolism: Overview01:27

Pharmacogenetics of Drug Metabolism: Overview

Genetic polymorphism in drug metabolism is crucial to the inter-individual variability observed in drug responses. Drug metabolism primarily involves the chemical modification of drugs and other xenobiotics to enhance their elimination by increasing their polarity. Two main classes of enzymes mediate this biotransformation process: Phase I enzymes, primarily cytochrome P450s, catalyze oxidation and reduction reactions, while other enzymes, such as esterases, mediate hydrolysis, and Phase II...
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...

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Farmacogenómica

Dan M Roden1, Howard L McLeod2, Mary V Relling3

  • 1Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.

Lancet (London, England)
|August 10, 2019
PubMed
Resumen
Este resumen es generado por máquina.

La medicina genómica utiliza la variación del ADN para la salud personalizada. Este estudio explora el uso de la variación genética para adaptar la terapia farmacológica, examinando sus mecanismos, datos clínicos e implementación en la práctica.

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Área de la Ciencia:

  • Medicina genómica
  • Farmacogenética
  • Terapia personalizada

Sus antecedentes:

  • La medicina genómica tiene como objetivo mejorar la salud aprovechando la variación del ADN.
  • La individualización de la terapia farmacológica basada en perfiles genéticos es un objetivo clave.
  • Comprender la variabilidad de la acción del fármaco es crucial para la medicina personalizada.

Objetivo del estudio:

  • Revisar los mecanismos de variabilidad de la acción del fármaco.
  • Explorar el papel de la variación genética en la farmacocinética y la farmacodinámica.
  • Evaluar los datos clínicos y la aplicación de la farmacogenética.

Principales métodos:

  • Revisión de la literatura sobre los mecanismos generales de variabilidad de la acción del fármaco.
  • Análisis del papel de la variación genética en la respuesta a los fármacos.
  • Examen de los datos de los ensayos clínicos y de las estrategias de aplicación.

Principales resultados:

  • La variación genética influye tanto en los efectos beneficiosos como en los adversos de los medicamentos.
  • Las concentraciones variables de fármacos (farmacocinética) y las acciones (farmacodinámica) están mediadas por factores genéticos.
  • Se están recopilando datos de ensayos clínicos y esfuerzos de implementación.

Conclusiones:

  • La farmacogenética tiene una promesa significativa para la individualización de la terapia farmacológica.
  • Se necesitan más investigaciones e implementación clínica para aprovechar todo el potencial de la medicina genómica.
  • La integración de la información genética en la práctica clínica es esencial para mejorar los resultados de los pacientes.