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Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder05:12

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Presented here is a protocol for the 2BC/CIE model of alcohol dependence in mice to study alcohol use disorder.
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Modeling Fetal Alcohol Spectrum Disorders in Zebrafish to Characterize the Impact of an Adverse Embryonic Environment on Adult Social Behavior04:58

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The goal of the current protocol is to outline the steps necessary to establish and use a social preference assay for adult zebrafish and demonstrate that it can be used to characterize ethanol-induced social...
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The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders19:57

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Trace eyeblink classical conditioning (ECC) was used to assess hippocampal-dependent associative learning in adult rats that were administered a high concentration (11.9% v/v) of alcohol during early neonatal brain development. In general, ECC procedures are sound diagnostic tools for detecting brain dysfunction across many psychological and biomedical...
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Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
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In this lesson, the oxidation of alcohols is discussed in depth. The various reagents used for oxidation of primary and secondary alcohols are detailed, and their mechanism of action is provided.
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Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
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Trastornos por consumo de alcohol

Andre F Carvalho1, Markus Heilig2, Augusto Perez3

  • 1Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

Lancet (London, England)
|September 4, 2019
PubMed
Resumen
Este resumen es generado por máquina.

Los trastornos por consumo de alcohol son afecciones de salud mental comunes que no reciben tratamiento debido al estigma y la falta de detección. La atención primaria debe implementar el cribado y las intervenciones de rutina para los trastornos por consumo de alcohol.

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Área de la Ciencia:

  • Salud pública
  • La salud mental
  • Medicina para la adicción

Sus antecedentes:

  • Los trastornos por consumo de alcohol (AUD) son condiciones de salud mental prevalentes en todo el mundo, especialmente en los países de altos ingresos.
  • Los AUD contribuyen significativamente a la mortalidad y la carga de enfermedades, a menudo vinculados a complicaciones médicas como la cirrosis hepática.
  • A pesar de los tratamientos efectivos, los AUD siguen siendo poco tratados debido al alto estigma y la detección insuficiente de la atención primaria.

Objetivo del estudio:

  • Resaltar la prevalencia y el impacto de los trastornos por consumo de alcohol.
  • Hacer hincapié en la necesidad de mejorar la detección y el tratamiento en los centros de atención primaria.
  • Abogar por estrategias de atención integradas y políticas de apoyo para el control del alcohol.

Principales métodos:

  • Revisión de la prevalencia mundial y las consecuencias de los trastornos por consumo de alcohol.
  • Análisis de las barreras al tratamiento, incluido el estigma y el cribado inadecuado.
  • Discusión de las intervenciones psicosociales y farmacológicas efectivas existentes.
  • Examen del papel de la atención primaria de la salud en la gestión de los AUD.
  • Consideración de las intervenciones a nivel político para la reducción del consumo de alcohol.

Principales resultados:

  • Los trastornos por consumo de alcohol son un importante problema de salud mundial con una mortalidad significativa.
  • El estigma y la falta de detección sistemática en la atención primaria impiden el acceso al tratamiento.
  • Existen intervenciones eficaces, incluidos consejos breves y tratamientos farmacológicos.
  • Los entornos de atención primaria son cruciales para el cribado de rutina y los enfoques de atención gradual.
  • Las políticas de apoyo para el control del alcohol pueden reducir el consumo y el impacto en general.

Conclusiones:

  • El cribado y la intervención de rutina para los trastornos por consumo de alcohol en la atención primaria son esenciales.
  • Se necesita un enfoque multifacético que combine intervenciones clínicas con políticas de apoyo.
  • Abordar el estigma y mejorar la integración del sistema de salud puede mejorar los resultados del tratamiento de AUD.