Video Experimental Relacionado

Updated: Jan 20, 2026

Covalently Linked Protein Regulators and Post-translational Modification

Covalently Linked Protein Regulators and Post-translational Modification

Cadros orgánicos covalentes enlazados con aminas a través de la condensación de aminas secundarias con aldehído

Shu-Yan Jiang^1,2, Shi-Xian Gan^1,3, Xi Zhang¹

¹Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Road , Shanghai 200032 , China.

Journal of the American Chemical Society

|September 8, 2019

Resumen

Los investigadores desarrollaron nuevos marcos orgánicos covalentes (COF) utilizando enlaces aminados, una nueva topología para los COF. Estos materiales demuestran propiedades fotofísicas conservadas y una excelente estabilidad, abriendo nuevas vías en la ciencia de los materiales.

Área de la Ciencia:

Ciencias de los materiales
Química orgánica
Nanotecnología

Sus antecedentes:

Los marcos orgánicos covalentes (COF) ofrecen diversidad estructural y propiedades ajustables.
El desarrollo de nuevas sustancias químicas de enlace para los FOC sigue siendo un desafío importante.
Los FOC existentes se enfrentan a menudo a limitaciones en cuanto a la retención de la propiedad y la estabilidad.

Objetivo del estudio:

Introducir y sintetizar las primeras estructuras orgánicas covalentes (COF) que emplean enlaces aminados.
Explorar las características estructurales y de propiedades de estos nuevos aminal-COF.
Investigar la estabilidad y las propiedades fotofísicas de los COF recién desarrollados.

Principales métodos:

Síntesis de aminal-COF mediante la condensación de aminas y aldehídos secundarios.
Análisis cristalográfico para determinar la topología de la red (cpi net).
Caracterización de la estabilidad fotofísica, térmica y química.

Principales resultados:

Se han sintetizado con éxito dos nuevos COF con enlaces aminados, una topología no reportada anteriormente (red cpi).
Los enlaces aminados conservan las propiedades fotofísicas de los monómeros debido a su naturaleza tetraédrica y no conjugada.
Los aminal-COF resultantes exhiben una robusta estabilidad térmica y una alta estabilidad química en entornos neutros y básicos.

Conclusiones:

Los enlaces aminados representan una nueva estrategia prometedora para el diseño de FOC con propiedades mejoradas.
La topología de la red cpi obtenida con enlaces aminados ofrece un nuevo motivo estructural para la investigación de COF.
Estos aminal-COF muestran potencial para aplicaciones que requieren materiales estables y fotofísicamente activos.

Más Videos Relacionados

Covalently Linked Protein Regulators

Covalently Linked Protein Regulators

Microfluidic-based Synthesis of Covalent Organic Frameworks COFs: A Tool for Continuous Production of COF Fibers and Direct Printing on a Surface

Microfluidic-based Synthesis of Covalent Organic Frameworks COFs: A Tool for Continuous Production of COF Fibers and Direct Printing on a Surface

Published on: July 10, 2017

Videos de Conceptos Relacionados

Covalently Linked Protein Regulators

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....

Covalently Linked Protein Regulators

Covalently Linked Protein Regulators

Microfluidic-based Synthesis of Covalent Organic Frameworks (COFs): A Tool for Continuous Production of COF Fibers and Direct Printing on a Surface

Microfluidic-based Synthesis of Covalent Organic Frameworks (COFs): A Tool for Continuous Production of COF Fibers and Direct Printing on a Surface

We present a novel microfluidic-based method for synthesis of covalent organic frameworks (COFs). We demonstrate how this approach can be used to produce continuous COF fibers, and also 2D or 3D COF structures on surfaces.

Preparation of Amines: Reductive Amination of Aldehydes and Ketones

Preparation of Amines: Reductive Amination of Aldehydes and Ketones

Carbonyl compounds and primary amines undergo reductive amination first to produce imines, followed by secondary amines in the same reaction mixture, using selective reducing agents like sodium cyanoborohydride or sodium triacetoxyborohydride. Reductive amination produces different degrees of substitution of amines depending on the starting amine substrate.

Nomenclature of Secondary and Tertiary Amines

Nomenclature of Secondary and Tertiary Amines

The secondary and tertiary amines are derivatives of ammonia, where two and three of its hydrogens are replaced by alkyl groups, respectively. Secondary and tertiary amines can be symmetrical with identical alkyl groups attached to the nitrogen atom or unsymmetrical when more than one type of alkyl group is present. The standard nomenclature of secondary and tertiary amines is similar to the names given to the primary amines. They are generally named alkylamines. As depicted in Figure 1, for...

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

A protocol is presented for the synthesis of information-encoded peptoid oligomers and for the sequence-directed self-assembly of these peptoids into molecular ladders using amines and aldehydes as dynamic covalent reactant pairs and Lewis acidic rare-earth metal triflates as multi-role...