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Sangrado y nuevo diagnóstico de cáncer en pacientes con aterosclerosis

John W Eikelboom¹, Stuart J Connolly¹, Jacqueline Bosch^1,2

¹Population Health Research Institute, McMaster University and Hamilton Health Sciences, Ontario, Canada (J.W.E., S.J.C., J.B., O.S., S.S.A., R.G.H., P.M., S.Y.).

|September 13, 2019

Resumen

La hemorragia en pacientes bajo tratamiento antitrombótico puede ser un signo de cáncer. El sangrado gastrointestinal o genitourinario aumenta significativamente el riesgo de nuevos diagnósticos de cáncer en estos sitios.

Área de la Ciencia:

Medicina cardiovascular
En el campo de la oncología
Investigación en ensayos clínicos

Sus antecedentes:

Los pacientes que toman medicamentos antitrombóticos se enfrentan a un mayor riesgo de sangrado.
Las hemorragias pueden ser un indicador temprano de un tumor maligno subyacente.

Objetivo del estudio:

Investigar la asociación entre el sangrado gastrointestinal (GI) o genitourinario (GU) y el diagnóstico posterior de nuevos cánceres.
Determinar la relación de riesgo para nuevos diagnósticos de cáncer después de eventos de sangrado GI o GU en pacientes del ensayo COMPASS.

Principales métodos:

Análisis de los datos del ensayo de resultados cardiovasculares para personas que usan estrategias de anticoagulación (COMPASS).
Nuevos diagnósticos de cáncer examinados en relación con eventos de sangrado GI o GU.
Coeficientes de riesgo calculados para el diagnóstico de cáncer después de la hemorragia.

Principales resultados:

Un total de 2678 (9,8%) pacientes experimentaron sangrado y 1084 (4,0%) fueron diagnosticados con cáncer.
El sangrado gastrointestinal mostró un aumento de 20,6 veces en el riesgo de cáncer gastrointestinal y 1,7 veces en el de cáncer no gastrointestinal.
La hemorragia urinaria mostró un aumento de 32,5 veces el riesgo de cáncer urinario, mientras que la hemorragia urinaria mostró un aumento de 98,5 veces el riesgo de cáncer urinario.

Conclusiones:

En pacientes con aterosclerosis tratados con antitrombóticos, el sangrado GI o GU está relacionado con tasas más altas de nuevos diagnósticos de cáncer.
Los médicos deben considerar la posibilidad de investigar el cáncer GI o GU cuando se producen estos eventos de sangrado.

Palabras clave:

La aspirina también.hemorragia en el cuerpo las neoplasias Rivaroxabán y sus derivados

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