Video Experimental Relacionado

Updated: Jan 5, 2026

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

Published on: June 8, 2022

Esfingosina 1-fosfato: señalización lipídica en patología y terapia

Andreane Cartier¹, Timothy Hla²

¹Vascular Biology Program, Boston Children's Hospital and Department of Surgery, Harvard Medical School, Boston, MA 02115, USA.

Science (New York, N.Y.)

|October 19, 2019

Resumen

El 1-fosfato de sfingosina (S1P) es un mediador lipídico clave que regula el desarrollo y la homeostasis a través de los receptores S1P (S1PR). La investigación pone de relieve la señalización S1PR

Área de la Ciencia:

Bioquímica y Biología Molecular
Inmunología
Biología cardiovascular

Sus antecedentes:

El 1-fosfato de esfingosina (S1P) es un mediador lipídico bioactivo derivado de los esfingolípidos.
S1P es transportado en la circulación y señala a través de receptores acoplados a proteínas G (S1PR).
La señalización S1PR es crucial para el desarrollo embrionario, la función de los órganos, el tráfico de células inmunes, el desarrollo vascular y la homeostasis.

Objetivo del estudio:

Revisar los principios fundamentales de la señalización S1P.
Resaltar el papel de las S1PR en la salud y la enfermedad.
Para discutir el potencial terapéutico de dirigirse a las S1PR.

Principales métodos:

Revisión de la literatura de la investigación multidisciplinaria sobre las S1P y las S1PR.
Análisis de las aplicaciones clínicas de los medicamentos dirigidos a S1PR.
Síntesis de los hallazgos sobre la señalización del mediador de lisofosfolípidos.

Principales resultados:

S1P y sus receptores (S1PRs) regulan una amplia gama de procesos fisiológicos.
La señalización desregulada de S1PR contribuye a varias enfermedades.
La orientación de las S1PR ha llevado a intervenciones clínicas exitosas.

Conclusiones:

La señalización S1P es un mecanismo fundamental con una amplia relevancia fisiológica y patológica.
Comprender la biología de S1P proporciona información crítica para el tratamiento de enfermedades inmunológicas, cardiovasculares, neurológicas, inflamatorias y fibróticas.
La investigación continua en las vías S1P promete nuevos avances terapéuticos.

Más Videos Relacionados

Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea

Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea

Published on: December 23, 2022

A Liposome Membrane Permeability Assay for Investigating the Effects of Phosphatidylinositol Phosphate Groups on Membranotropic Action of Venom PLA2

A Liposome Membrane Permeability Assay for Investigating the Effects of Phosphatidylinositol Phosphate Groups on Membranotropic Action of Venom PLA₂

Published on: September 26, 2025

Videos de Conceptos Relacionados

IP3/DAG Signaling Pathway

IP3/DAG Signaling Pathway

Membrane lipids such as phosphatidylinositol (PI) are precursors for several membrane-bound and soluble second messengers. Specific kinases phosphorylate PI and produce phosphorylated inositol phospholipids. One such inositol phospholipids are the phosphatidylinositol-4,5 bisphosphate [PI(4,5)P2], present in the inner half of the lipid bilayer. Upon ligand binding, GPCR stimulates Gq proteins to turn on phospholipase Cꞵ. Activated phospholipase Cꞵ cleaves PI(4,5)P2 and...

Phosphoinositides and PIPs

Phosphoinositides and PIPs

Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...

Signal Transduction: Overview

Signal Transduction: Overview

Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...

Notch Signaling Pathway

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...

Amplifying Signals via Enzymatic Cascade

Amplifying Signals via Enzymatic Cascade

When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze...

The JAK-STAT Signaling Pathway

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...