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The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
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Induction and Validation of Cellular Senescence in Primary Human Cells
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La senescencia celular: la definición de un camino hacia adelante

Vassilis Gorgoulis1, Peter D Adams2, Andrea Alimonti3

  • 1Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece; Biomedical Research Foundation, Academy of Athens, Athens, Greece; Faculty Institute for Cancer Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK; Center for New Biotechnologies and Precision Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Cell
|November 2, 2019
PubMed
Resumen
Este resumen es generado por máquina.

Este consenso define los biomarcadores de la senescencia celular y proporciona una herramienta, SeneQuest, para identificar los genes asociados a la senescencia. Ofrece un algoritmo para una evaluación precisa de la senescencia en las células e in vivo, ayudando a la investigación de la senoterapia.

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Área de la Ciencia:

  • Biología celular y molecular
  • Gerontología
  • Descubrimiento de biomarcadores

Sus antecedentes:

  • La senescencia celular es un factor clave en el envejecimiento y las enfermedades relacionadas con la edad.
  • La orientación terapéutica de la senescencia (senoterapia) es un campo de rápido crecimiento.
  • La detección precisa de las células senescentes in vivo es crucial para el desarrollo de la senoterapia.

Objetivo del estudio:

  • Establecer un consenso sobre la definición y detección de la senescencia celular.
  • Proporcionar recomendaciones para el uso de las características de senescencia como biomarcadores.
  • Para introducir el recurso SeneQuest y un algoritmo de evaluación de la senescencia.

Principales métodos:

  • Desarrollo consensuado por la Asociación Internacional de Senescencia Celular (ICSA).
  • Definición y discusión de las características clave de la senescencia celular y molecular.
  • Desarrollo de la herramienta de identificación genética SeneQuest y de un algoritmo de cuantificación de la senescencia.

Principales resultados:

  • Se proporciona una definición de consenso y características clave de la senescencia celular.
  • Se ofrecen recomendaciones para la utilización de biomarcadores de la senescencia.
  • Se presenta la herramienta SeneQuest y un nuevo algoritmo de evaluación de la senescencia.

Conclusiones:

  • La identificación precisa de las células senescentes es esencial para el avance de la senoterapia.
  • El consenso de ICSA, SeneQuest y el algoritmo propuesto facilitan la investigación de la senescencia.
  • Estos recursos apoyan el desarrollo de intervenciones para el envejecimiento saludable y las enfermedades relacionadas con la edad.