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Ácidos nucleicos peptídicos bilingües: codificación de los lenguajes de los ácidos nucleicos y las proteínas en un

Colin S Swenson¹, Arventh Velusamy¹, Hector S Argueta-Gonzalez¹

¹Department of Chemistry , Emory University , Atlanta , Georgia 30322 , United States.

Journal of the American Chemical Society

|November 13, 2019

Resumen

Los investigadores desarrollaron un biopolímero bilingüe, integrando secuencias de aminoácidos y nucleobases en un andamio de ácido nucleico peptídico (PNA). Este nuevo material exhibe autoensamblaje programable y respuestas específicas de secuencia para aplicaciones biomédicas avanzadas.

Área de la Ciencia:

Biotecnología
Química de los polímeros
Biología molecular

Sus antecedentes:

Los ácidos nucleicos y las proteínas son biopolímeros esenciales, que almacenan información en secuencias distintas.
Los biopolímeros actuales codifican por separado información de nucleótidos o aminoácidos.
Esta separación limita las aplicaciones en medicina y biotecnología.

Objetivo del estudio:

Para diseñar y sintetizar un nuevo biopolímero bilingüe.
Para integrar las secuencias de aminoácidos y nucleobases en un solo andamio de ácido nucleico peptídico (PNA).
Para lograr el almacenamiento sintonizable y la recuperación del comportamiento estructural terciario y el reconocimiento molecular programable.

Principales métodos:

Diseño y síntesis de un biopolímero de ácido nucleico peptídico bilingüe (PNA).
Incorporación de cadenas laterales de aminoácidos para crear un "código de proteína" para el autoensamblaje.
Introducción de una cadena de ARN complementaria para desencadenar una interrupción específica de la secuencia a través de la hibridación.

Principales resultados:

El PNA bilingüe forma moléculas anfifílicas que dirigen el autoensamblaje en arquitecturas micelares.
El "código de nucleótido" permite la interrupción específica de la secuencia de estos conjuntos tras la introducción de ARN complementario.
Almacenamiento y recuperación sintonizables demostrados de comportamiento estructural terciario y reconocimiento molecular programable.

Conclusiones:

El PNA bilingüe combina dos sistemas de información (códigos de aminoácidos y bases nucleares) en un solo andamio.
Esto ofrece una plataforma poderosa para aprovechar la capacidad de respuesta estructural y el reconocimiento de secuencias.
El andamio PNA es generalizable para diversas aplicaciones biomédicas y nanotecnológicas.

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