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Toxicidad multisistémico en el cáncer: lecciones del programa de contramedidas de la NASA
Jessica M Scott1, Lianne B Dolan2, Larry Norton1
1Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Medical College, New York, NY, USA.
Cell
|November 16, 2019
Resumen
La NASA también.
Área de la Ciencia:
- Fisiología del vuelo espacial
- En el campo de la oncología
- Medicina traslacional
Sus antecedentes:
- El vuelo espacial induce toxicidades fisiológicas multisistémicas.
- Los tratamientos contra el cáncer también causan toxicidades significativas.
- Estas toxicidades comparten puntos en común entre los astronautas y los pacientes con cáncer.
Objetivo del estudio:
- Proponer un nuevo programa de contramedidas (CMP) basado en la investigación de vuelos espaciales de la NASA.
- Investigar la aplicación de estrategias derivadas de los vuelos espaciales para mitigar las toxicidades relacionadas con el cáncer.
- Para aclarar y anular las toxicidades fisiológicas en pacientes con cáncer.
Principales métodos:
- Aprovechando la amplia experiencia de la NASA en la caracterización y mitigación de los efectos fisiológicos de los vuelos espaciales.
- Adaptar las contramedidas establecidas a los desafíos únicos de la atención de los pacientes con cáncer.
- Desarrollo de un marco para un CMP modelado por la NASA en oncología.
Principales resultados:
- El CMP propuesto ofrece un enfoque único para controlar los efectos secundarios del tratamiento del cáncer.
- Identifica posibles superposiciones en las respuestas fisiológicas al vuelo espacial y la terapia del cáncer.
- Proporciona una base para futuras investigaciones sobre nuevas estrategias terapéuticas.
Conclusiones:
- Un CMP modelado por la NASA es prometedor para mejorar la calidad de vida de los pacientes con cáncer.
- Los enfoques interdisciplinarios pueden dar lugar a soluciones innovadoras en la medicina.
- Se necesita más investigación para validar e implementar este enfoque.
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