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Las gotas de Coacervate complejo multifásico

Tiemei Lu1, Evan Spruijt1

  • 1Institute for Molecules and Materials , Radboud University , Heyendaalseweg 135 , 6525 AJ , Nijmegen , The Netherlands.

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|January 22, 2020
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Resumen
Este resumen es generado por máquina.

La separación de fase líquido-líquido multicomponente forma gotas organizadas jerárquicamente. Las diferencias en la densidad macromolecular y la concentración crítica de sal predicen la formación de gotas y la estratificación en los sistemas biológicos.

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Área de la Ciencia:

  • La biofísica
  • Biología celular
  • Ciencias de los materiales

Sus antecedentes:

  • La organización celular se basa en la separación de fase líquido-líquido (LLPS).
  • Los cuerpos subcelulares exhiben una organización jerárquica con múltiples dominios coexistentes.
  • Los mecanismos moleculares que rigen el ensamblaje y la coexistencia de gotas multicomponentes siguen sin estar claros.

Objetivo del estudio:

  • Investigar la formación y organización de gotas multifásicas estructuradas jerárquicamente.
  • Desarrollar directrices teóricas para predecir la disposición jerárquica y la separación de fases.
  • Explorar el potencial de la inmiscibilidad del condensado para el diseño de compartimentos sintéticos.

Principales métodos:

  • Se utilizaron coacervados complejos como sistemas modelo para LLPS impulsados por carga.
  • Se analizaron las tensiones interfaciales y las concentraciones críticas de sal.
  • Diferencias de densidad macromolecular investigadas en mezclas de coacervados.

Principales resultados:

  • Se ha demostrado una organización jerárquica en gotas multifásicas con hasta tres capas coexistentes.
  • Se establecieron pautas teóricas que correlacionan las tensiones interfaciales y la concentración crítica de sal con la estructura de gotas.
  • Se demostró que las diferencias en la densidad macromolecular y la concentración crítica de sal predicen la coexistencia de los coacervados.
  • Se observaron entornos químicos distintos dentro de los coacervados coexistentes, que influyen en la concentración de moléculas invitadas.

Conclusiones:

  • Las gotas multifásicas organizadas jerárquicamente son un fenómeno genérico en mezclas complejas de coacervados.
  • La inmiscibilidad del condensado es probablemente una característica general en los sistemas biológicos.
  • Los hallazgos proporcionan un marco para comprender y diseñar compartimentos sintéticos autoorganizados para procesos biomoleculares.