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Un nuevo coronavirus asociado con una enfermedad respiratoria humana en China

Fan Wu¹, Su Zhao², Bin Yu³

¹Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.

|February 5, 2020

Resumen

Un nuevo coronavirus, designado WH-Human 1 (2019-nCoV), fue identificado en un brote de enfermedad respiratoria grave en Wuhan, China. Este virus, vinculado a un mercado de mariscos, es genéticamente similar a los coronavirus de murciélagos, lo que pone de relieve los riesgos de contagio zoonótico.

Área de la Ciencia:

Virología
Epidemiología
Salud pública

Sus antecedentes:

Las enfermedades infecciosas emergentes representan una amenaza significativa para la salud mundial.
Los orígenes y los patrones de aparición de nuevos patógenos siguen siendo inciertos.
Se identificó un brote de enfermedad respiratoria grave en Wuhan, China.

Objetivo del estudio:

Para identificar el agente causante de la enfermedad respiratoria grave en Wuhan.
Para entender las características virales y los orígenes del nuevo patógeno.

Principales métodos:

Secuenciación del ARN metagenómico del líquido de lavado broncoalveolar de un paciente afectado.
Análisis filogenético del genoma viral completo.

Principales resultados:

Se identificó un nuevo virus de ARN, el coronavirus WH-Human 1 (2019-nCoV), de la familia Coronaviridae.
El virus está filogenéticamente estrechamente relacionado con los coronavirus similares al SARS que se encuentran en murciélagos.
Se determinó la secuencia completa del genoma viral.

Conclusiones:

El coronavirus identificado es una nueva cepa responsable del brote de Wuhan.
Los hallazgos subrayan el riesgo de eventos de contagio zoonóticos que conducen a enfermedades humanas graves.
Se requiere una mayor investigación sobre los coronavirus de murciélago para comprender las amenazas potenciales de pandemia.

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