Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Role of Neurotransmitters in Memory01:23

Role of Neurotransmitters in Memory

2.3K
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
 Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
2.3K
Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

1.8K
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
1.8K
Long-term Depression01:03

Long-term Depression

3.0K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
3.0K
Long-term Depression01:05

Long-term Depression

32.9K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
32.9K
Forgetting01:21

Forgetting

303
Forgetting is an intrinsic aspect of human memory, characterized by the gradual loss or inaccessibility of information over time. Hermann Ebbinghaus, a pioneering psychologist, extensively studied this phenomenon and formulated the forgetting curve. This curve illustrates that memory loss occurs rapidly immediately after learning and then decelerates over time. Several mechanisms contribute to forgetting, including encoding failure, storage decay, retrieval failure, and interference.
Encoding...
303
Interference and Decay01:16

Interference and Decay

368
Forgetting is a complex cognitive phenomenon influenced by several factors, among which interference and decay are particularly prominent. These processes explain why individuals often struggle to retrieve specific information from memory, leading to lapses in recall that can be observed in everyday situations.
Interference occurs when competing memories hinder the retrieval of particular information. It can be classified into two types: proactive and retroactive interference. Proactive...
368

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

The Impact of Climate Change on the Spatial Distribution of Seven <i>Meconopsis</i> Species in China: A MaxEnt Model-Based Predictive Analysis.

Ecology and evolution·2026
Same author

Development of a multimodal large language model for early warning and diagnosis of chronic ocular GVHD.

NPJ digital medicine·2026
Same author

Steam reforming of biomass tar using the low-cost incineration bottom ash as catalyst.

Journal of environmental management·2026
Same author

Potential roles of plant metabolites and Traditional Chinese Medicine formulas in regulating glycolysis-OXPHOS plasticity in gastric precancerous lesions and gastric cancer: a critical appraisal of the evidence.

Frontiers in pharmacology·2026
Same author

Integrating multi-omics and epiphytic microbial communities to decipher the spatiotemporal dynamics of flower color dynamic regulation in <i>Hibiscus mutabilis</i>.

Frontiers in plant science·2026
Same author

The QseB/QseC two-component system modulates virulence, motility, and outer membrane vesicles biogenesis in Salmonella enteritidis.

Microbial pathogenesis·2026
Same journal

A native sulfur deposit in Gale crater, Mars.

Science (New York, N.Y.)·2026
Same journal

Coordinated demise of harmful algal blooms.

Science (New York, N.Y.)·2026
Same journal

Genetic effects put into context.

Science (New York, N.Y.)·2026
Same journal

Bacteria share proteins to survive antibiotics.

Science (New York, N.Y.)·2026
Same journal

Impacts shaped Earth's first continents.

Science (New York, N.Y.)·2026
Same journal

Erratum for the Report "Covalently bonded single-molecule junctions with stable and reversible photoswitched conductivity" by C. Jia <i>et al</i>.

Science (New York, N.Y.)·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: Dec 29, 2025

Author Spotlight: Advancing Understanding Through Technological Innovations in Psychoneuroimmunology
07:41

Author Spotlight: Advancing Understanding Through Technological Innovations in Psychoneuroimmunology

Published on: May 31, 2024

1.8K

Olvido del mediado por microglia a través de la eliminación sináptica dependiente del complemento

Chao Wang1,2, Huimin Yue1,2, Zhechun Hu1,2

  • 1Institute of Neuroscience and Department of Neurology of the Second Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou 310058, China.

Science (New York, N.Y.)
|February 8, 2020
PubMed
Resumen
Este resumen es generado por máquina.

La microglia envuelve las sinapsis en el cerebro, causando el olvido de la memoria. La inhibición de este proceso, particularmente las vías del complemento, previene la pérdida de memoria y preserva las conexiones de las células del engrama.

Más Videos Relacionados

A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes
06:43

A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes

Published on: February 5, 2018

12.6K
Selective Depletion of Microglia from Cerebellar Granule Cell Cultures Using L-leucine Methyl Ester
08:10

Selective Depletion of Microglia from Cerebellar Granule Cell Cultures Using L-leucine Methyl Ester

Published on: July 7, 2015

9.0K

Videos de Experimentos Relacionados

Last Updated: Dec 29, 2025

Author Spotlight: Advancing Understanding Through Technological Innovations in Psychoneuroimmunology
07:41

Author Spotlight: Advancing Understanding Through Technological Innovations in Psychoneuroimmunology

Published on: May 31, 2024

1.8K
A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes
06:43

A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes

Published on: February 5, 2018

12.6K
Selective Depletion of Microglia from Cerebellar Granule Cell Cultures Using L-leucine Methyl Ester
08:10

Selective Depletion of Microglia from Cerebellar Granule Cell Cultures Using L-leucine Methyl Ester

Published on: July 7, 2015

9.0K

Área de la Ciencia:

  • La neurociencia
  • Inmunología
  • Investigación de la memoria

Sus antecedentes:

  • Las sinapsis en las células del engrama son cruciales para el almacenamiento de la memoria.
  • La pérdida de memoria está asociada con el debilitamiento o la pérdida de estas sinapsis.
  • La microglia, las células inmunes del cerebro, están implicadas en la plasticidad sináptica.

Objetivo del estudio:

  • Para investigar el papel de la microglia en el olvido de recuerdos remotos.
  • Elucidar los mecanismos por los cuales la microglía contribuye a la degradación de la memoria.
  • Para determinar si las vías del complemento están involucradas en el olvido microglial.

Principales métodos:

  • Observación de la envoltura microglial de los componentes sinápticos en el hipocampo del ratón.
  • Agotamiento de la microglía e inhibición de la fagocitosis microglial.
  • Introducción de CD55 para inhibir las vías del complemento en las células del engrama.
  • Evaluación de la retención de la memoria y la disociación de las células del engrama.

Principales resultados:

  • Se observó una envoltura microglial de componentes sinápticos en ratones adultos sanos.
  • El agotamiento de la microglía o la inhibición de su fagocitosis impidió el olvido de la memoria.
  • La inhibición de las vías del complemento en las células del engrama también impidió el olvido.
  • La microglía estuvo involucrada tanto en la neurogénesis como en la degradación de la memoria no relacionada.

Conclusiones:

  • La microglía elimina las sinapsis de una manera dependiente del complemento y dependiente de la actividad, lo que lleva al olvido de la memoria.
  • La eliminación de sinapsis dependiente del complemento por la microglía es un mecanismo clave para el olvido de recuerdos remotos.
  • Dirigirse a la actividad microglial y a las vías del complemento puede ofrecer estrategias para combatir la pérdida de memoria.