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Características epidemiológicas y curso clínico de los pacientes infectados con SARS-CoV-2 en Singapur
Barnaby Edward Young1,2,3, Sean Wei Xiang Ong1,2, Shirin Kalimuddin4,5
1National Centre for Infectious Diseases, Singapore.
JAMA
|March 4, 2020
Resumen
Los 18 pacientes iniciales con síndrome respiratorio agudo severo por coronavirus 2 (SARS-CoV-2) en Singapur a menudo tenían síntomas leves, pero algunos requerían oxígeno. El tratamiento con lopinavir-ritonavir mostró resultados y efectos secundarios variables en este estudio temprano del brote de SARS-CoV-2.
Área de la Ciencia:
- Enfermedades infecciosas
- Virología
- Salud pública
Sus antecedentes:
- El coronavirus 2 del síndrome respiratorio agudo severo (SARS-CoV-2) surgió a finales de 2019, causando una pandemia global.
- Comprender las características clínicas y epidemiológicas iniciales del SARS-CoV-2 es crucial para un manejo eficaz.
Objetivo del estudio:
- Para describir la experiencia inicial en Singapur con el SARS-CoV-2.
- Investigar la epidemiología, las características clínicas y el manejo de los primeros casos.
Principales métodos:
- Una serie de casos descriptivos de 18 pacientes con infección por SARS-CoV-2 confirmada por PCR.
- Los datos recopilados incluyeron hallazgos clínicos, de laboratorio y radiológicos, derramamiento viral y resultados del tratamiento.
- El seguimiento se llevó a cabo hasta el 25 de febrero de 2020.
Principales resultados:
- La mayoría de los pacientes (67%) presentaron infecciones de las vías respiratorias superiores; el 33% requirió oxígeno suplementario y 2 requirieron cuidados intensivos.
- Se observó una secreción viral prolongada desde la nasofaringe (≥7 días) en el 83% de los pacientes.
- El virus fue detectado en heces y sangre, pero no en orina. El tratamiento con lopinavir-ritonavir produjo resultados variables y efectos adversos.
Conclusiones:
- Las primeras infecciones por SARS-CoV-2 en Singapur se presentan comúnmente como enfermedades respiratorias leves.
- Los resultados clínicos fueron variados y el tratamiento con lopinavir-ritonavir mostró eficacia mixta y efectos secundarios notables.
- Este estudio proporciona información sobre el espectro clínico inicial y los desafíos de manejo del SARS-CoV-2.
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