Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Protecting Groups for Aldehydes and Ketones: Introduction01:23

Protecting Groups for Aldehydes and Ketones: Introduction

8.6K
Protecting groups are compounds that can bind to a specific functional group in the presence of other functional groups to protect them from undesired chemical reactions. These compounds can selectively bind to particular functional groups and advance chemoselective reactions in polyfunctional systems (Figure 1). After the functional group has served its purpose, it is removed by reacting it with specific compounds.
8.6K
Catenins01:23

Catenins

2.9K
Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the...
2.9K
Aromatic Hydrocarbon Cations: Structural Overview01:18

Aromatic Hydrocarbon Cations: Structural Overview

3.6K
Cycloheptatriene is a neutral monocyclic unsaturated hydrocarbon that consists of an odd number of carbon atoms and an intervening sp3 carbon in the ring. The three double bonds in the ring correspond to 6 π electrons, which is a Huckel number, and therefore satisfies the criteria of 4n + 2 π electrons. However, the intervening sp3 carbon disrupts the continuous overlap of p orbitals. As a result, cycloheptatriene is not aromatic.
Removing one hydrogen from the intervening CH2 group...
3.6K
Aromatic Hydrocarbon Anions: Structural Overview01:18

Aromatic Hydrocarbon Anions: Structural Overview

3.5K
Neutral hydrocarbons like cyclopentadiene with an odd number of carbon atoms and one intervening CH2 group in the ring are not aromatic. Cyclopentadiene with 4 π electrons does not satisfy the 4n + 2 π electron rule. Additionally, the intervening CH2 group is sp3 hybridized and lacks a vacant p orbital, thereby interrupting the overlap of p orbitals in a continuous manner and preventing the delocalization of π electrons throughout the ring.
Due to the absence of continuous...
3.5K
Acetals and Thioacetals as Protecting Groups for Aldehydes and Ketones01:24

Acetals and Thioacetals as Protecting Groups for Aldehydes and Ketones

5.5K
Acetals are formed by reacting two equivalents of alcohol with carbonyl compounds like aldehydes or ketones. Acetals are unaffected by bases, nucleophiles, oxidizing agents, and reducing agents. They serve as protecting groups for aldehydes and ketones. Acetals can be easily formed and also easily removed via mild acid hydrolysis.
In the presence of multiple functional groups, when selective reduction of one group over the other is desired, groups like aldehydes and ketones that form acetals...
5.5K
Tension Response at Adherens Junctions01:26

Tension Response at Adherens Junctions

3.4K
The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin...
3.4K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Weak Bond, Strong Response: Complete Activation and Efficient Cargo Release with a Furan/Acrylamide Mechanophore.

Journal of the American Chemical Society·2026
Same author

Template-Controlled Mechanochemical Dissociation of a Rotaxane.

Angewandte Chemie (International ed. in English)·2025
Same author

Force-Induced Ring Flipping in a Threaded Pillar[5]Arene.

Angewandte Chemie (International ed. in English)·2025
Same author

Selective Scission of Orthogonal Bonds in Four-Membered Ring Mechanophores upon Activation by a Rotaxane Actuator.

Angewandte Chemie (International ed. in English)·2025
Same author

A focus on substituents effect in the force-promoted disrotatory ring-opening of <i>cis</i>-cyclobutenes.

Chemical science·2025
Same author

A Mechanochromic Rotaxane that Releases Azetidine-Trityl-Maleimide, a Versatile Fluorescent Probe.

Angewandte Chemie (International ed. in English)·2025

Video Experimental Relacionado

Updated: Dec 27, 2025

Accessing Valuable Ligand Supports for Transition Metals: A Modified, Intermediate Scale Preparation of 1,2,3,4,5-Pentamethylcyclopentadiene
09:45

Accessing Valuable Ligand Supports for Transition Metals: A Modified, Intermediate Scale Preparation of 1,2,3,4,5-Pentamethylcyclopentadiene

Published on: March 20, 2017

10.8K

Una catena como grupo de protección mecánica

Min Zhang1, Guillaume De Bo1

  • 1Department of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom.

Journal of the American Chemical Society
|March 6, 2020
PubMed
Resumen

Los mecanóforos son moléculas que responden a la fuerza. Los investigadores encontraron que un [2]catenano actúa como un escudo mecánico, protegiendo a los grupos activos mediante la distribución de la tensión a través de sus anillos.

Más Videos Relacionados

Preparation of 6-aminocyclohepta-2,4-dien-1-one Derivatives via Tricarbonyltroponeiron
07:56

Preparation of 6-aminocyclohepta-2,4-dien-1-one Derivatives via Tricarbonyltroponeiron

Published on: August 12, 2019

8.2K
Isolating Free Carbenes, their Mixed Dimers and Organic Radicals
10:44

Isolating Free Carbenes, their Mixed Dimers and Organic Radicals

Published on: April 19, 2019

11.4K

Videos de Experimentos Relacionados

Last Updated: Dec 27, 2025

Accessing Valuable Ligand Supports for Transition Metals: A Modified, Intermediate Scale Preparation of 1,2,3,4,5-Pentamethylcyclopentadiene
09:45

Accessing Valuable Ligand Supports for Transition Metals: A Modified, Intermediate Scale Preparation of 1,2,3,4,5-Pentamethylcyclopentadiene

Published on: March 20, 2017

10.8K
Preparation of 6-aminocyclohepta-2,4-dien-1-one Derivatives via Tricarbonyltroponeiron
07:56

Preparation of 6-aminocyclohepta-2,4-dien-1-one Derivatives via Tricarbonyltroponeiron

Published on: August 12, 2019

8.2K
Isolating Free Carbenes, their Mixed Dimers and Organic Radicals
10:44

Isolating Free Carbenes, their Mixed Dimers and Organic Radicals

Published on: April 19, 2019

11.4K

Área de la Ciencia:

  • Química supramolecular
  • Ciencias de los materiales
  • Química de los polímeros

Sus antecedentes:

  • Los mecanóforos son moléculas que exhiben cambios en respuesta a la fuerza mecánica aplicada.
  • La respuesta mecánica de los mecanóforos se puede modular alterando su estructura molecular o la matriz de polímero circundante.
  • Desarrollar un control preciso sobre la actividad de los mecanifores es crucial para crear materiales avanzados que respondan a la fuerza.

Objetivo del estudio:

  • Investigar el potencial de un [2]catenano como grupo protector mecánico para los mecanóforos.
  • Para explorar las capacidades de desviación de fuerza de los anillos entrelazados en un sistema de catenas.
  • Establecer una nueva estrategia para el control de la activación mecánica de los mecanóforos.

Principales métodos:

  • Síntesis y caracterización de un [2]catenano que incorpora un grupo funcional mecánicamente activo.
  • Pruebas mecánicas para evaluar la respuesta de la fuerza del grupo funcional en el marco de la catena.
  • Análisis de la movilidad del anillo de la catena y su efecto en la distribución de la tensión.

Principales resultados:

  • El [2]catenano funcionó efectivamente como un grupo de protección mecánica.
  • Las fuerzas de tensión fueron desviadas con éxito del mecanóforo incrustado por los anillos móviles de la catenana.
  • La rotación de los anillos catenanos permitió la equalización de la tensión en todo el marco molecular.

Conclusiones:

  • La movilidad de los anillos [2]catenanos les permite actuar como un escudo mecánico, protegiendo los mecanifóforos incrustados.
  • Este trabajo introduce un nuevo método para controlar la actividad de los mecanóforos a través del diseño supramolecular.
  • Los hallazgos abren vías para el desarrollo de materiales sofisticados que responden a la fuerza con comportamientos mecánicos ajustables.