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Renovar la lucha contra la tuberculosis con una vacuna antigua
Thomas J Scriba1, Valerie Mizrahi2
1South African Tuberculosis Vaccine Initiative and Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Cell
|March 7, 2020
Resumen
La prevención de la infección y la enfermedad por tuberculosis es posible en primates mediante la vacuna BCG administrada por vía intravenosa. Este avance ofrece una nueva estrategia para desarrollar vacunas eficaces contra la tuberculosis.
Área de la Ciencia:
- Inmunología
- Vacunas y vacunas
- Enfermedades infecciosas
Sus antecedentes:
- La prevención de la tuberculosis pulmonar (TB) a través de la vacunación sigue siendo un importante desafío para la salud mundial.
- La eficacia de las vacunas existentes, como Bacillus Calmette-Guérin (BCG), en la prevención de la infección y la enfermedad de la tuberculosis es limitada, especialmente en los adultos.
Objetivo del estudio:
- Investigar el potencial de la vacunación BCG administrada a través de una vía alternativa para mejorar la prevención de la tuberculosis.
- Evaluar la eficacia de la administración intravenosa de BCG en la prevención de la infección y la enfermedad de la tuberculosis en un modelo de primates no humanos.
Principales métodos:
- Se administró la vacuna BCG por vía intravenosa a primates no humanos.
- Los primates vacunados fueron posteriormente infectados con Mycobacterium tuberculosis.
- Se monitoreó la infección y la progresión de la enfermedad.
Principales resultados:
- La administración intravenosa de la vacuna BCG evitó con éxito la infección y la enfermedad de la tuberculosis en primates no humanos.
- Este enfoque demostró una mejora significativa con respecto a los métodos de vacunación tradicionales.
Conclusiones:
- La vacunación intravenosa BCG representa una nueva estrategia prometedora para la prevención de la tuberculosis.
- Este hallazgo podría conducir a un cambio de paradigma en el desarrollo de nuevas vacunas contra la tuberculosis.
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