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Conjuntos neuronales funcionalmente distintos dentro del engrama de memoria

Xiaochen Sun1, Max J Bernstein2, Meizhen Meng2

  • 1McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Molecular and Cellular Neuroscience Graduate Program, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Cell
|March 19, 2020
PubMed
Resumen
Este resumen es generado por máquina.

Distintos conjuntos neuronales dentro de los engramas de memoria controlan la generalización frente a la discriminación. Las vías dependientes de Fos promueven la generalización, mientras que las vías dependientes de Npas4 impulsan la discriminación mediante la modulación de las entradas sinápticas y la actividad interneurónica.

Palabras clave:
CCK ((+) las interneuronasLos demásNpas4vías dependientes de la actividadGiro dentadocorteza entorrinal medialDiscriminación de la memoriaengramas de memoriageneralización de la memoriaconjuntos neuronales

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Área de la Ciencia:

  • La neurociencia
  • Biología molecular
  • Neurociencia de los sistemas

Sus antecedentes:

  • Se cree que los engramas de memoria involucran conjuntos neuronales escasos.
  • La heterogeneidad funcional dentro de estos engramas de memoria no se entiende bien.
  • No está claro si las subpoblaciones neuronales distintas codifican aspectos específicos de la memoria.

Objetivo del estudio:

  • Para investigar la heterogeneidad funcional dentro de los engramas de memoria.
  • Para identificar distintas subpoblaciones neuronales que codifican aspectos de la memoria.
  • Para aclarar los mecanismos de circuito subyacentes a la generalización de la memoria y la discriminación.

Principales métodos:

  • Utilizó modelos de ratón para estudiar los engramas de memoria de miedo contextuales en el giro dentado.
  • Se emplean marcadores genéticos (Fos y Npas4) para definir subpoblaciones neuronales.
  • Investigó las entradas sinápticas y la actividad de las interneuronas utilizando electrofisiología y trazado de circuitos.

Principales resultados:

  • Identificaron conjuntos neuronales funcionalmente distintos dentro de los engramas de memoria, definidos por las vías Fos o Npas4.
  • El conjunto Fos-dependiente promueve la generalización de la memoria a través de entradas excitadoras mejoradas de la corteza entorrinal medial.
  • El conjunto dependiente de Npas4 promueve la discriminación de la memoria a través del impulso inhibidor de las interneuronas de colecistoquinina.

Conclusiones:

  • Proporcionó evidencia causal para la heterogeneidad funcional dentro del engrama de memoria.
  • Reveló distintos mecanismos sinápticos y de circuitos para la generalización y la discriminación de la memoria.
  • Destacó el papel de conjuntos neuronales específicos en el equilibrio de la generalización de la memoria y la discriminación.