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Estrategias de orientación para la administración de fármacos específicos de los tejidos
Zongmin Zhao1, Anvay Ukidve1, Jayoung Kim1
1John A. Paulson School of Engineering and Applied Sciences, Harvard University, MA 02138, USA; Wyss Institute of Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA.
Cell
|April 4, 2020
Resumen
Las estrategias de focalización mejoran la eficacia del medicamento al permitir la administración específica del sitio, superar las barreras biológicas y reducir los efectos fuera del objetivo. Esta revisión analiza los avances en las pequeñas moléculas, el ácido nucleico, el péptido, los anticuerpos y los enfoques basados en células para la administración de fármacos específicos de los tejidos.
Área de la Ciencia:
- Farmacología
- Entrega de drogas
- Ingeniería biomédica
Sus antecedentes:
- La administración sistémica de fármacos se enfrenta a desafíos con efectos fuera del objetivo, lo que afecta la eficacia terapéutica y la toxicidad.
- Las barreras biológicas impiden la administración efectiva de fármacos específicos de los tejidos, lo que requiere estrategias avanzadas.
- Superar estas barreras es crucial para desarrollar terapias más seguras y efectivas.
Objetivo del estudio:
- Revisar los avances clave y los conceptos emergentes en la administración de fármacos específicos de los tejidos.
- Discutir estrategias para superar las barreras biológicas a la administración de medicamentos.
- Para explorar la traducción clínica de varios enfoques de orientación de medicamentos.
Principales métodos:
- Revisión de la literatura de estudios preclínicos y clínicos sobre las estrategias de orientación de fármacos.
- Análisis de sistemas de administración basados en pequeñas moléculas, ácido nucleico, péptido, anticuerpos y células.
- Discusión de las barreras biológicas y métodos para superarlas.
Principales resultados:
- Se han desarrollado múltiples estrategias de orientación durante tres décadas.
- Estas estrategias incluyen moléculas pequeñas, ácido nucleico, péptido, anticuerpo y enfoques basados en células.
- Se han logrado avances significativos en la modulación de la administración de fármacos para tejidos específicos.
Conclusiones:
- La administración de fármacos específicos de los tejidos es muy prometedora para reducir los efectos no dirigidos y la toxicidad.
- La investigación continua para superar las barreras biológicas es esencial para el avance terapéutico.
- La traducción de estas estrategias de orientación a la práctica clínica es un foco clave para el futuro desarrollo de fármacos.
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