Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.8K
Clinical Trials01:16

Clinical Trials

10.1K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
10.1K
Clinical Trials: Overview01:11

Clinical Trials: Overview

4.4K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
4.4K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.6K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

335
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
335

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Leveraging clinical decision support to minimize sedation gaps in patients receiving rocuronium for rapid sequence intubation.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists·2026
Same author

A Response to Blanc and Colleagues' Viewpoint on Gestalt Language Processing and the Natural Language Acquisition Protocol: Concerns and Common Ground.

Perspectives of the ASHA special interest groups·2026
Same author

From prompting to practice: Empowering faculty with AI and prompting tools.

Nurse education today·2026
Same author

An AI Approach to Differentiating Lung Squamous Cell Carcinoma From Metastases of Other Origins.

JAMA network open·2026
Same author

Socioecological Perspectives on Healing After Child Sexual Abuse: An Application of the National Institute of Minority Health and Health Disparities Research Framework.

Journal of child sexual abuse·2026
Same author

HSP90α and KLK6 Coregulate Stress-Induced Prostate Cancer Cell Motility.

Cells·2026

Video Experimental Relacionado

Updated: Dec 25, 2025

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
13:24

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

12.2K

Tipo de ensayo en la medicina de precisión

Dane Dickson1, Jennifer Johnson2, Raymond Bergan3

  • 1Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA; Taproot Health, Salt Lake City, UT, USA.

Cell
|April 4, 2020
PubMed
Resumen

La comprensión de las relaciones entre biomarcadores y resultados clínicos es clave para el diagnóstico de precisión y los tratamientos personalizados. Los ensayos maestros observacionales ofrecen un enfoque eficiente para recopilar datos clínicos amplios y de alta calidad.

Más Videos Relacionados

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

7.7K
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.5K

Videos de Experimentos Relacionados

Last Updated: Dec 25, 2025

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
13:24

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

12.2K
Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

7.7K
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.5K

Área de la Ciencia:

  • Metodologías de investigación clínica
  • Descubrimiento y validación de biomarcadores
  • Medicina personalizada

Sus antecedentes:

  • La integración de diagnósticos de precisión con tratamientos personalizados requiere comprender las relaciones entre los biomarcadores y los resultados clínicos.
  • Los métodos de recopilación de datos clínicos existentes, incluidos los datos de intervención y del mundo real (RWD), tienen limitaciones en cuanto a calidad, alcance o eficiencia.
  • Los protocolos maestros mejoran la eficiencia de la recopilación de datos.

Objetivo del estudio:

  • Explorar el papel de los ensayos maestros observacionales para cerrar la brecha entre los estudios intervencionistas y la recolección retrospectiva de RWD.
  • Destacar la importancia de comprender las correlaciones entre los biomarcadores y los resultados clínicos para el avance de la medicina personalizada.

Principales métodos:

  • Revisión de las estrategias de recolección de datos clínicos existentes (intervención, RWD).
  • Introducción del ensayo observacional maestro como una nueva metodología.
  • Discusión de los protocolos maestros para la adquisición eficiente de datos.

Principales resultados:

  • Los datos de intervención ofrecen una alta calidad pero un alcance limitado.
  • Los datos del mundo real (RWD, por sus siglas en inglés) proporcionan información amplia pero de calidad variable.
  • Los ensayos observacionales maestros presentan un enfoque equilibrado para la recopilación de datos.

Conclusiones:

  • Los ensayos observacionales maestros pueden mejorar la eficiencia y la calidad de la recopilación de datos para la investigación de biomarcadores.
  • Esta metodología apoya la integración de diagnósticos de precisión en estrategias de tratamiento personalizadas.
  • Se requiere una mayor investigación de los ensayos observacionales maestros para optimizar la adquisición de datos clínicos.