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Definición de los principios de diseño del crecimiento posnatal de la epidermis de la piel
Sophie Dekoninck1, Edouard Hannezo2, Alejandro Sifrim3
1Université Libre de Bruxelles, Laboratory of Stem Cells and Cancer, Brussels 1070, Belgium.
Cell
|April 8, 2020
Resumen
El crecimiento de órganos postnatales depende de progenitores de desarrollo con tasas de proliferación decrecientes. La expansión de la epidermis de la piel está guiada por la orientación local de la fibra de colágeno para el crecimiento armónico del tejido.
Área de la Ciencia:
- Biología del desarrollo
- Ingeniería de tejidos
- Dinámica de las células
Sus antecedentes:
- Los órganos crecen durante el desarrollo, pero los mecanismos de crecimiento postnatal no están claros.
- Comprender la dinámica celular es clave para la expansión de los tejidos y la organogénesis.
Objetivo del estudio:
- Para aclarar la dinámica celular que rige la expansión de la epidermis de la piel postnatal.
- Identificar las características de las células progenitoras y los factores ambientales que influyen en el crecimiento.
Principales métodos:
- Trazabilidad del linaje clonal in vivo
- Análisis de la cinética de la proliferación
- Transcriptómica de una sola célula
- Experimentos con micro patrones in vitro
Principales resultados:
- El crecimiento cutáneo postnatal es impulsado por una población progenitora uniforme con tasas de proliferación decrecientes.
- Los progenitores del desarrollo epidérmico son más uniformes que las células madre / progenitoras adultas.
- La orientación de la división celular está regulada espacialmente por la alineación de las fibras de colágeno.
Conclusiones:
- El crecimiento armónico de órganos implica progenitores con dinámicas específicas de auto-renovación y proliferación.
- La expansión del tejido está influenciada por el microambiente local, incluida la matriz extracelular.
- Un simple principio de diseño rige la expansión coordinada de las células y los tejidos durante el desarrollo.
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