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Protein Networks

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

Protein Networks

Protein Networks

Protein-protein Interfaces

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...

Protein-Protein Interfaces

Protein-Protein Interfaces

Protein Complexes with Interchangeable Parts

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...

Protein Complexes with Interchangeable Parts

Protein Complexes with Interchangeable Parts

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Updated: Dec 24, 2025

Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay PCA in Living Cells

Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay PCA in Living Cells

Published on: March 3, 2015

Un mapa de referencia del interactoma de la proteína binaria humana

Katja Luck^1,2,3, Dae-Kyum Kim^1,4,5,6, Luke Lambourne^1,2,3

¹Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.

|April 17, 2020

Resumen

Este resumen es generado por máquina.

Los investigadores crearon la red de interacción proteína-proteína humana, HuRI, que tiene un mapa de 53.000 interacciones. Este mapa integral del interactoma ayuda a comprender las relaciones genotipo-fenotipo y las funciones celulares.

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Área de la Ciencia:

Biología molecular
La genómica
Biología de sistemas

Sus antecedentes:

Comprender la organización celular y la función del genoma es crucial para vincular el genotipo con el fenotipo.
Los datos existentes sobre las interacciones proteína-proteína son limitados en escala y alcance.

Objetivo del estudio:

Presentar un mapa integral de interactomas de referencia para todos los seres humanos, llamado HuRI.
Permitir el estudio de las funciones celulares dentro de varios contextos fisiológicos y patológicos mediante la integración de datos de interactomas con datos genómicos, transcriptómicos y proteómicos.

Principales métodos:

Construcción de un mapa de interacción proteína-proteína binario humano "todo por todo" (HuRI).
Integración del mapa HuRI con conjuntos de datos de genoma, transcriptoma y proteoma.
Inferencia de redes específicas de tejidos desde el mapa de HuRI.

Principales resultados:

HuRI contiene aproximadamente 53,000 interacciones proteína-proteína binarias humanas, expandiendo significativamente los conjuntos de datos curados existentes.
Utilidad demostrada de HuRI en la identificación de funciones subcelulares específicas de las interacciones proteína-proteína.
Las redes específicas de tejidos inferidas revelaron los principios de las funciones específicas del contexto celular y los mecanismos potenciales para las enfermedades mendelianas.

Conclusiones:

HuRI sirve como un mapa de referencia sistemático de todo el proteoma para las interacciones de proteínas humanas.
El mapa facilita el estudio de las relaciones genotipo-fenotipo y las funciones celulares.
HuRI ayuda a dilucidar los mecanismos moleculares subyacentes a los fenotipos y enfermedades específicos de los tejidos.