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Los medicamentos multispecíficos anuncian una nueva era de innovación biofarmacéutica
1Amgen Research, Thousand Oaks, CA, USA. rdii2003@gmail.com.
Nature
|April 17, 2020
Resumen
Los medicamentos multispecíficos representan una cuarta ola de innovación biofarmacéutica, que ofrece nuevas formas de desarrollar terapias dirigidas. Estas moléculas de fármacos avanzados tienen el potencial de ampliar las posibilidades de tratamiento para enfermedades previamente inalcanzables.
Área de la Ciencia:
- Industria biofarmacéutica
- Desarrollo de drogas
- Tratamientos moleculares
Sus antecedentes:
- La evolución de la industria biofarmacéutica comenzó con la aspirina a principios del siglo XX.
- El descubrimiento de fármacos vio grandes cambios con el descubrimiento racional de fármacos (1970s) y las proteínas recombinantes (1980s).
- Está surgiendo una nueva era de medicamentos multispecíficos.
Objetivo del estudio:
- Revisar las dos clases principales de medicamentos multispecíficos.
- Explorar el potencial de los fármacos multispecíficos para redefinir las estrategias terapéuticas.
- Para resaltar cómo los medicamentos multispecíficos pueden dirigirse a componentes proteómicos previamente inaccesibles.
Principales métodos:
- Revisión de la literatura existente sobre el desarrollo de fármacos multispecíficos.
- Categoría de las drogas multispecíficas en dos clases principales.
- Análisis de los mecanismos funcionales y el potencial terapéutico de cada clase.
Principales resultados:
- Los fármacos multispecíficos se clasifican en agentes de enriquecimiento del sitio y de enlace del efector objetivo.
- Los fármacos de enlace efector objetivo ofrecen mecanismos novedosos al desacoplar la unión de la modulación directa del objetivo.
- Este enfoque puede desbloquear intervenciones terapéuticas para objetivos actualmente no farmacológicos.
Conclusiones:
- Las drogas multispecíficas representan un avance significativo en el desarrollo de fármacos.
- Estos medicamentos pueden superar potencialmente las limitaciones de las moléculas terapéuticas tradicionales.
- El desarrollo de fármacos multispecíficos promete ampliar el alcance de la medicina de precisión.
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