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Wei Rao¹, Shan Wang¹, Marcin Duleba¹

¹Stem Cell Center, Department of Biology and Biochemistry, University of Houston, Houston, TX 77003, USA.

|April 17, 2020

Resumen

Las células progenitoras variantes en los pulmones impulsan la patología de la enfermedad pulmonar obstructiva crónica (EPOC). Estas células, normalmente raras, se expanden en los pulmones con EPOC, causando inflamación y daño tisular.

Área de la Ciencia:

Medicina de los pulmones
Biología celular
Inmunología

Sus antecedentes:

La enfermedad pulmonar obstructiva crónica (EPOC) es un problema de salud mundial importante caracterizado por la inflamación, la fibrosis y la metaplasia.
Los orígenes y las relaciones de estas características patológicas en la EPOC siguen siendo poco conocidos.

Objetivo del estudio:

Investigar los orígenes celulares de la patología de la EPOC utilizando tecnologías de clonación de una sola célula.
Identificar y caracterizar las células progenitoras variantes en los pulmones con EPOC.

Principales métodos:

Clonado unicelular aplicado al tejido pulmonar de pacientes con EPOC y controles.
Trasplante de clones progenitoras variantes aisladas en ratones con inmunodeficiencia.
Análisis histopatológico e inmunológico de la patología pulmonar inducida.

Principales resultados:

Los pulmones de EPOC, a diferencia de los pulmones de control, estaban dominados por tres células progenitoras variantes epigenéticamente comprometidas.
El trasplante de estos clones variantes recapituló las principales patologías de la EPOC, incluida la metaplasia mucosa y escamosa, la inflamación neutrófila y la fibrosis.
Existen variantes progenitoras similares en cantidades menores en los pulmones normales y fetales, potencialmente involucradas en la vigilancia inmune.

Conclusiones:

Las células progenitoras variantes, normalmente en reposo, se expanden en la EPOC y impulsan la patogénesis de la enfermedad.
Estas variantes expandidas son responsables de la inflamación característica, la metaplasia y la fibrosis observadas en la EPOC.
Comprender la expansión y la función de estas variantes progenitoras ofrece objetivos terapéuticos potenciales para la EPOC.

Palabras clave:

Enfermedad pulmonar obstructiva crónica Enfermedad pulmonar crónica Fibrosis en el cuerpo inflamación el pulmón Metaplasia en el cuerpo Miofibroblastos y sus derivados Los neutrófilos P1 y P2 clonación de una sola célula Células madre

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