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El SARS-CoV-2 y la sepsis viral: observaciones e hipótesis

Hui Li¹, Liang Liu², Dingyu Zhang³

¹Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Beijing, China; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Lancet (London, England)

|April 21, 2020

Resumen

Los pacientes con COVID-19 graves pueden experimentar un shock debido a la sepsis viral. Esta hipótesis, basada en la autopsia y la investigación científica básica, guía los estudios futuros sobre la patogénesis de la enfermedad por coronavirus 2019.

Área de la Ciencia:

Enfermedades infecciosas
Patología
Medicina de cuidados intensivos

Sus antecedentes:

La enfermedad por coronavirus 2019 (COVID-19) presenta diversas características clínicas.
Los casos graves de COVID-19 presentan manifestaciones de choque como extremidades frías, incluso sin hipotensión.
Comprender los mecanismos subyacentes del COVID-19 es crucial para el manejo efectivo de los pacientes.

Objetivo del estudio:

Proponer una hipótesis sobre la patogénesis del COVID-19.
Para investigar el papel de la sepsis viral en el COVID-19 severo.
Para guiar las futuras direcciones de investigación en la ciencia básica de COVID-19.

Principales métodos:

Revisión de los hallazgos de la autopsia en pacientes con COVID-19.
Análisis de la investigación científica básica sobre el SARS-CoV-2 y el SARS-CoV.
Discusión multidisciplinaria entre expertos en patología, ciencia básica y atención clínica.

Principales resultados:

Hipotetizó que la sepsis viral es un mecanismo clave en la patogénesis de COVID-19.
Manifestaciones de choque identificadas en pacientes con COVID-19 graves.
Propuso un marco para comprender la patogénesis del SARS-CoV-2.

Conclusiones:

La sepsis viral es un factor potencialmente crucial en el COVID-19 severo.
Las hipótesis propuestas requieren una mayor validación a través de la investigación básica.
Este trabajo proporciona una base para futuras investigaciones sobre los mecanismos del COVID-19.

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