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Mejoramiento selectivo de PP2A a través de la estabilización de heterotrimeros sesgados

Daniel Leonard1, Wei Huang2, Sudeh Izadmehr3

  • 1Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA; Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.

Cell
|April 22, 2020
PubMed
Resumen

Una nueva molécula, DT-061, estabiliza la enzima B56α-PP2A, mejorando su actividad contra objetivos de cáncer como c-Myc. Este descubrimiento ofrece nuevas estrategias terapéuticas para enfermedades que involucran la disfunción de la proteína fosfatasa 2A (PP2A).

Palabras clave:
B56αEl PP2AEl SMAPc-Mycel cáncerCrio-EMFósfatasa y sus derivadosmolécula pequeña

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