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Identificación de la ALK en términos de delgadez
Michael Orthofer1, Armand Valsesia2, Reedik Mägi3
1IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna 1030, Austria.
Cell
|May 23, 2020
Resumen
Los investigadores identificaron la linfoma anaplásica quinasa (ALK) como un gen clave que contribuye a la delgadez. Este gen juega un papel en la regulación del peso corporal y la resistencia a la obesidad.
Área de la Ciencia:
- La genética
- El metabolismo
- La neurociencia
Sus antecedentes:
- La susceptibilidad individual al aumento de peso varía significativamente.
- La investigación sobre la obesidad a menudo se centra en las predisposiciones genéticas al aumento de peso, pasando por alto los factores que contribuyen a la delgadez.
Objetivo del estudio:
- Para identificar los genes asociados con el mantenimiento de un físico delgado saludable.
- Investigar el papel de la linfoma kinasa anaplásica (ALK) en la regulación del peso corporal y la prevención de la obesidad.
Principales métodos:
- Estudio de asociación genómica (GWAS) en una cohorte estonia delgada y saludable desde el punto de vista metabólico.
- Estudios de eliminación genética en Drosophila y estudios de deleción genética en ratones.
- Investigación del papel de la ALK en las neuronas del hipotálamo y el control del sistema nervioso simpático del tejido adiposo.
Principales resultados:
- La linfoma anaplásica quinasa (ALK) fue identificada como un gen candidato para la delgadez.
- Knockdown de Alk en Drosophila redujo los niveles de triglicéridos.
- La deleción genética de Alk en ratones resultó en delgadez y resistencia a la obesidad inducida por la dieta y la mutación de la leptina.
- La ALK en las neuronas del hipotálamo regula el gasto de energía a través del control simpático de la lipólisis del tejido adiposo.
Conclusiones:
- La linfoma quinasa anaplásica (ALK) es un factor importante para mantener un peso corporal delgado y saludable.
- La ALK funciona en el hipotálamo para controlar el gasto de energía y la lipólisis, lo que confiere resistencia al aumento de peso.
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