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El ensamblaje gradual del viroma neonatal está modulado por la lactancia materna
Guanxiang Liang1,2, Chunyu Zhao2, Huanjia Zhang2
1Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Nature
|May 29, 2020
Resumen
El intestino del bebé
Área de la Ciencia:
- Microbiología
- Virología
- Salud neonatal
Sus antecedentes:
- El intestino del bebé normalmente está libre de virus al nacer pero coloniza rápidamente.
- La colonización viral a veces puede conducir a problemas gastrointestinales en los recién nacidos.
Objetivo del estudio:
- Para aclarar el montaje paso a paso de la comunidad viral en los recién nacidos.
- Investigar los orígenes y la dinámica de las poblaciones virales en el intestino infantil.
Principales métodos:
- Secuenciación metagenómica enriquecida con virus y comunidades microbianas enteras.
- Coloración fluorescente de partículas parecidas a los virus.
- Análisis microbiológicos específicos.
Principales resultados:
- La colonización viral ocurre en pasos distintos, comenzando con los bacteriófagos de las bacterias pioneras.
- En un mes, los bacteriófagos dominan; en cuatro meses, los virus que infectan a los humanos aumentan.
- La lactancia materna influye en la composición de la comunidad viral, y los bebés alimentados con fórmula muestran una mayor abundancia de virus humanos.
Conclusiones:
- La colonización viral intestinal infantil es un proceso gradual iniciado por bacteriófagos y más tarde influenciado por virus humanos.
- La lactancia juega un papel importante en la modulación del viroma intestinal del bebé.
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