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Updated: Dec 20, 2025

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El modulador alostérico de β-arrestina de NTSR1 atenúa selectivamente las conductas adictivas

Lauren M Slosky1, Yushi Bai1, Krisztian Toth2

  • 1Department of Cell Biology, Duke University, Durham, NC 27710, USA.

Cell
|May 30, 2020
PubMed
Resumen

SBI-553, un nuevo modulador del receptor de la neurotensina 1 (NTSR1), trata eficazmente los modelos de abuso de drogas al dirigirse selectivamente a la señalización de la β-arrestina. Este enfoque evita los efectos secundarios, ofreciendo una estrategia terapéutica más segura para los trastornos psiquiátricos.

Palabras clave:
Repetor acoplado a proteínas GGPCR y sus derivadosNTSR1 (en inglés)El PETadicciónModulador alostéricoLa cocaínaLa dopamina tambiénMetanfetamina y sus derivadosreceptor de la neurotensina 1Tomografía por emisión de positronesautoadministraciónLas demás sustancias

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