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Los hexosomas de polímeros vesiculares muestran defectos topológicos

Chin Ken Wong1, Markus Heidelmann2, Martin Dulle3

  • 1Physical Chemistry, University of Münster, Corrensstraße 28-30, 48149 Münster, Germany.

Journal of the American Chemical Society
|June 2, 2020
PubMed
Resumen
Este resumen es generado por máquina.

Los investigadores descubrieron nuevos hexosomas de polímero con estructuras no circulares y cuatro defectos topológicos. Estos "hexosomas vesiculares" son huecos y ofrecen potencial para aplicaciones de administración de fármacos.

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Área de la Ciencia:

  • Ciencias de los materiales
  • Química de los polímeros
  • Nanotecnología

Sus antecedentes:

  • Los hexosomas de polímero son morfologías de copolímero de bloque con una fase hexagonal inversa (HII).
  • Por lo general, los hexosomas de polímero son rotativamente simétricos, formando aros circulares a partir de cilindros invertidos giratorios.

Objetivo del estudio:

  • Informar sobre la formación de hexosomas poliméricos con estructuras no circulares.
  • Investigar las propiedades y aplicaciones potenciales de estas nuevas estructuras.

Principales métodos:

  • Autoensamblaje de copolímeros de bloque en solución.
  • Caracterización estructural de las morfologías resultantes.
  • Análisis de defectos topológicos y morfología.

Principales resultados:

  • Formación de hexosomas de polímero con aros no circulares debido a la orientación invertida inusual del cilindro.
  • Generación de cuatro defectos topológicos en la estructura hexosómica.
  • Identificación de estas estructuras como huecas, que se asemejan a los polimerosomas con una cáscara cilíndrica hexagonal inversa.

Conclusiones:

  • Estos "hexosomas vesiculares" con defectos presentan una nueva plataforma para el anclaje espacial de ligandos y biomoléculas.
  • El caparazón hueco y la luz pueden acomodar diferentes cargas.
  • Un mecanismo de formación de dos pasos propuesto implica la separación de la fase líquido-líquido seguida de la separación de la microfase del polímero, que difiere de las vías convencionales.