Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

3.6K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
3.6K
Chemical Synapses01:26

Chemical Synapses

4.0K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
4.0K
Chemical Synapses01:26

Chemical Synapses

11.0K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
11.0K
The Synapse02:47

The Synapse

132.0K
Neurons communicate with one another by passing on their electrical signals to other neurons. A synapse is the location where two neurons meet to exchange signals. At the synapse, the neuron that sends the signal is called the presynaptic cell, while the neuron that receives the message is called the postsynaptic cell. Note that most neurons can be both presynaptic and postsynaptic, as they both transmit and receive information.
132.0K
Excitatory and Inhibitory Effects of Neurotransmitters01:29

Excitatory and Inhibitory Effects of Neurotransmitters

12.3K
When an action potential reaches the presynaptic axon terminal, it releases neurotransmitters from the neuron into the synaptic cleft at a chemical synapse. The released neurotransmitter can be excitatory or inhibitory. The critical criteria commonly used to determine whether a molecule is a neurotransmitter at a chemical synapse are the molecule's presence in the presynaptic neuron. Second, its release is in response to strong presynaptic depolarization. And lastly, the presence of...
12.3K
Ligand-gated Ion Channels01:19

Ligand-gated Ion Channels

13.7K
Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that...
13.7K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Alzheimer's Tau seeds-induced pathology enhances hippocampal extracellular diffusion.

Communications biology·2025
Same author

Diverse anti-NMDAR autoantibodies from individuals with encephalitis.

Nature structural & molecular biology·2024
Same author

Synaptic rearrangement of NMDA receptors controls memory engram formation and malleability in the cortex.

Science advances·2024
Same author

Activity-dependent diffusion trapping of AMPA receptors as a key step for expression of early LTP.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2024
Same author

Positive Allosteric Modulation of NMDARs Prevents the Altered Surface Dynamics Caused by Patients' Antibodies.

Neurology(R) neuroimmunology & neuroinflammation·2024
Same author

NMDA receptor autoantibodies primarily impair the extrasynaptic compartment.

Brain : a journal of neurology·2024
Same journal

Erratum for the Research Article "Detecting supramolecular organic nanoparticles during heat wave".

Science (New York, N.Y.)·2026
Same journal

Local signals, systemic decline.

Science (New York, N.Y.)·2026
Same journal

The mechanics of liver regeneration.

Science (New York, N.Y.)·2026
Same journal

Computing in a memory with physics.

Science (New York, N.Y.)·2026
Same journal

Retraction.

Science (New York, N.Y.)·2026
Same journal

Making time.

Science (New York, N.Y.)·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: Dec 18, 2025

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice
08:27

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice

Published on: March 11, 2020

6.5K

La vinculación de los movimientos de los receptores de glutamato y la función de la sinapsis

Laurent Groc1,2, Daniel Choquet1,2,3

  • 1Interdisciplinary Institute for NeuroScience, CNRS, UMR 5297, Centre Broca Nouvelle-Aquitaine, 146, rue Léo-Saignat, 33076 Bordeaux, France. laurent.groc@u-bordeaux.fr daniel.choquet@u-bordeaux.fr.

Science (New York, N.Y.)
|June 13, 2020
PubMed
Resumen
Este resumen es generado por máquina.

Los niveles de receptores sinápticos son controlados por el movimiento, crucial para la plasticidad y función del cerebro. Comprender la dinámica de estos receptores ofrece información sobre los trastornos neurológicos.

Más Videos Relacionados

Fast Micro-iontophoresis of Glutamate and GABA: A Useful Tool to Investigate Synaptic Integration
07:08

Fast Micro-iontophoresis of Glutamate and GABA: A Useful Tool to Investigate Synaptic Integration

Published on: July 31, 2013

20.0K
A High-content Assay for Monitoring AMPA Receptor Trafficking
10:34

A High-content Assay for Monitoring AMPA Receptor Trafficking

Published on: January 28, 2019

7.9K

Videos de Experimentos Relacionados

Last Updated: Dec 18, 2025

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice
08:27

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice

Published on: March 11, 2020

6.5K
Fast Micro-iontophoresis of Glutamate and GABA: A Useful Tool to Investigate Synaptic Integration
07:08

Fast Micro-iontophoresis of Glutamate and GABA: A Useful Tool to Investigate Synaptic Integration

Published on: July 31, 2013

20.0K
A High-content Assay for Monitoring AMPA Receptor Trafficking
10:34

A High-content Assay for Monitoring AMPA Receptor Trafficking

Published on: January 28, 2019

7.9K

Área de la Ciencia:

  • La neurociencia
  • Plasticidad sináptica
  • Biología molecular

Sus antecedentes:

  • La regulación de los receptores neurotransmisores es vital para la función sináptica.
  • El tráfico de receptores dentro y fuera de las sinapsis es un mecanismo clave para la plasticidad postsináptica.
  • Los avances tecnológicos han permitido el estudio detallado de la dinámica de los receptores.

Objetivo del estudio:

  • Para revisar la última comprensión de los movimientos de los receptores en las sinapsis.
  • Para resaltar el papel del tráfico de receptores en la eficacia sináptica.
  • Para discutir las implicaciones para la salud del cerebro y la enfermedad.

Principales métodos:

  • Concéntrese en dos receptores glutamatérgicos clave.
  • Revisión de los avances tecnológicos en el etiquetado y seguimiento de receptores.
  • Análisis de métodos para interferir con los movimientos de los receptores.

Principales resultados:

  • Los movimientos de los receptores son procesos altamente regulados.
  • Estos movimientos median la plasticidad postsináptica.
  • Comprender la dinámica de los receptores es crucial para la transmisión sináptica.

Conclusiones:

  • El tráfico de receptores es fundamental para la plasticidad sináptica.
  • La desregulación de los movimientos de los receptores puede contribuir a enfermedades cerebrales.
  • Las investigaciones adicionales sobre la dinámica de los receptores pueden informar las estrategias terapéuticas.