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Types of Membrane Protrusions01:28

Types of Membrane Protrusions

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The protrusion of the cell surface is an initial step for several cellular processes, including cell migration, phagocytosis, and neurite outgrowth. These membrane protrusions are a result of cytoskeletal rearrangement. The most  widely observed cell protrusions include lamellipodia, pseudopodia, filopodia, microvilli, invadopodia, and podosomes. These protrusions can be of two types — static or dynamic.
The microvilli, an example of stable protrusions, are finger-like projections...
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Nose and Nasal Cavity01:24

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The nose is composed of an observable exterior segment (external nose) and an internal segment within the skull known as the nasal cavity (internal nose). The external nose, visible on the face, consists of a framework of bone and hyaline cartilage enveloped in skin and muscle and lined with a mucous membrane. This structure is supported by the frontal bone, nasal bones, and maxillary bone and is supplemented by a cartilaginous framework comprising the septal nasal cartilage, lateral nasal...
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The oral cavity, or the mouth, is a complex structure in humans that plays a vital role in our day-to-day lives. Its role is not only in chewing and swallowing food; it also plays a role in speech and facial expressions.
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Cranial Bones: Lateral View01:27

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The lateral view of the cranium is dominated by temporal, sphenoid, and ethmoid bones.
The temporal bone forms the lower lateral side of the skull. The temporal bone is subdivided into several regions. The flattened upper portion is the squamous portion of the temporal bone. Below this area and projecting anteriorly is the zygomatic process of the temporal bone, which forms the posterior portion of the zygomatic arch. Posteriorly is the mastoid portion of the temporal bone. Projecting...
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The cadherins were one of the first cell adhesion molecules discovered; the term “cadherins”   is based on their calcium-dependent adhering properties. The first cadherins discovered on the epithelial, neuronal, and placental cells were named E-cadherin, P-cadherin, and N-cadherin, respectively. These classical cadherins share sequence and structural similarities. Other cadherins, including those involved in cell signaling, are grouped into non-classical cadherins. This...
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Pinching-off of Coated Vesicles01:32

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Vesicle budding is orchestrated by distinct cytosolic proteins such as adaptor proteins, coat proteins, and GTPases. To initiate vesicle budding, membrane-bending proteins containing crescent-shaped BAR domains bind to the lipid heads in the bilayer and distort the membrane to form a protein-coated vesicle bud. Adaptors proteins such as AP2 for clathrin-coated vesicles can nucleate on the deformed membrane. Finally, coat proteins such as clathrin or COPI and COPII assemble into a coat forming...
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Video Experimental Relacionado

Updated: Dec 17, 2025

Author Spotlight: Three-Dimensional Cephalometric Landmark Annotation Demonstration on Human Cone Beam Computed Tomography Scans
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Coronoides de gran cavidad con estructuras de borde interior y exterior diferentes

Marco Di Giovannantonio1, Xuelin Yao2, Kristjan Eimre1

  • 1Empa, Swiss Federal Laboratories for Materials Science and Technology, nanotech@surfaces Laboratory, 8600 Dübendorf, Switzerland.

Journal of the American Chemical Society
|June 27, 2020
PubMed
Resumen
Este resumen es generado por máquina.

Los investigadores sintetizaron nuevos hidrocarburos aromáticos policíclicos llamados coronoides con grandes cavidades, que sirven como modelos para el grafeno poroso. Estas estructuras presentan bordes únicos en zigzag interno y externo, lo que abre posibilidades para aplicaciones de anfitrión-invitado.

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Área de la Ciencia:

  • Ciencias de los materiales
  • Química orgánica
  • Nanotecnología

Sus antecedentes:

  • Los coronoides son hidrocarburos aromáticos policíclicos (HAP) con cavidades geométricamente definidas.
  • Son estructuras modelo prometedoras para comprender el grafeno poroso.
  • La síntesis en la superficie permite la creación de arquitecturas moleculares complejas.

Objetivo del estudio:

  • Para informar la síntesis en la superficie de coronoides específicos, C168 ([6]coronoide) y C140 ([5]coronoide).
  • Investigar las propiedades estructurales y electrónicas de estos coronoides sintetizados.
  • Para explorar su potencial para aplicaciones host-guest.

Principales métodos:

  • Síntesis en la superficie utilizando el 5,9-dibromo-14-fenilbenzo[m]tetrafeno como precursor.
  • Microscopía/espectroscopia de túnel de barrido a baja temperatura (LT-STM/STS).
  • Microscopía de fuerza atómica sin contacto (NC-AFM).
  • Cálculos de la teoría funcional de la densidad (DFT).

Principales resultados:

  • Síntesis exitosa de C168 ([6]coronoide) y C140 ([5]coronoide).
  • Las coronoides poseen grandes cavidades (> 1 nm) con bordes zigzagueantes interiores y exteriores de sillón.
  • [6]coronoide es plano, mientras que [5]coronoide exhibe no-planaridad.
  • Los resultados experimentales se alinean con los cálculos de DFT con respecto a las propiedades estructurales y electrónicas.
  • El análisis del efecto de corriente de anillo identificó anillos altamente aromáticos que coinciden con sus estructuras Clar.

Conclusiones:

  • Las coronoides sintetizadas sirven como sistemas modelo valiosos para el grafeno poroso.
  • Las estructuras de cavidad únicas y las configuraciones de borde ofrecen potencial para el reconocimiento molecular.
  • Una mayor funcionalidad de los poros podría conducir a aplicaciones avanzadas de anfitrión-invitado.