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Transductores moleculares del consorcio de actividad física (MoTrPAC): mapeo de las respuestas dinámicas al ejercicio
James A Sanford1, Christopher D Nogiec2, Malene E Lindholm3
1Pacific Northwest National Laboratory, Richland, WA 99354, USA.
Cell
|June 27, 2020
Resumen
El ejercicio regular mejora la salud al activar señales moleculares. Los Transductores Moleculares de la Actividad Física (MoTrPAC) tienen como objetivo mapear estas señales para comprender los beneficios del ejercicio y la prevención de enfermedades.
Área de la Ciencia:
- Fisiología del ejercicio
- Biología molecular
- Biología de los sistemas
Sus antecedentes:
- El entrenamiento físico aumenta la capacidad fisiológica y reduce el riesgo de mortalidad.
- Las señales moleculares específicas que median los beneficios para la salud del ejercicio no se comprenden completamente.
Objetivo del estudio:
- Abordar la brecha de conocimiento mediante la creación de un mapa molecular completo del ejercicio.
- Para identificar las señales moleculares inducidas por la actividad física.
Principales métodos:
- Realización de estudios preclínicos y clínicos sobre ejercicios de resistencia.
- Analizando datos multi-ómicos de varios tejidos antes y después del ejercicio agudo y crónico.
- Utilización de enfoques bioinformáticos para el análisis de datos.
Principales resultados:
- Establecimiento de un mapa molecular del ejercicio a través de análisis multiómicos y bioinformáticos integrados.
- Generar una base de datos pública de cambios moleculares inducidos por el ejercicio.
Conclusiones:
- La iniciativa MoTrPAC avanzará significativamente en nuestra comprensión de los beneficios para la salud del ejercicio.
- Esta investigación proporciona información sobre los mecanismos por los que la actividad física previene las enfermedades.
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