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Factores asociados con las muertes relacionadas con el COVID-19 con OpenSAFELY
Elizabeth J Williamson1, Alex J Walker2, Krishnan Bhaskaran1
1London School of Hygiene and Tropical Medicine, Faculty of Epidemiology and Population Health, London, UK.
Nature
|July 9, 2020
Resumen
Este estudio identificó factores de riesgo clave para la muerte por COVID-19, incluido el sexo masculino, la edad avanzada y ciertas afecciones médicas. Los grupos étnicos minoritarios, en particular los individuos negros y del sur de Asia, se enfrentaron a riesgos más altos incluso después de los ajustes.
Área de la Ciencia:
- Salud pública
- Epidemiología
- Informática de la salud
Sus antecedentes:
- La enfermedad del coronavirus 2019 (COVID-19) ha causado una mortalidad global significativa.
- Comprender los factores de riesgo para los resultados graves de COVID-19 es crucial para las intervenciones de salud pública.
- El análisis oportuno de datos de pacientes a gran escala es esencial para identificar a las poblaciones en riesgo.
Objetivo del estudio:
- Examinar los factores asociados con las muertes relacionadas con el COVID-19 utilizando una plataforma segura de análisis de la salud.
- Identificar los predictores demográficos, socioeconómicos y clínicos de la mortalidad en una gran cohorte de adultos.
- Proporcionar pruebas para estrategias específicas de salud pública y gestión clínica.
Principales métodos:
- Utilizó OpenSAFELY, una plataforma segura de análisis de salud que cubre el 40% de los pacientes de Inglaterra.
- Registros electrónicos de salud de atención primaria vinculados pseudónimamente de 17.278.392 adultos con 10.926 muertes relacionadas con el COVID-19.
- Se utilizó el análisis de supervivencia para determinar los coeficientes de riesgo de varios factores de riesgo.
Principales resultados:
- El sexo masculino, el aumento de la edad y la privación se asociaron significativamente con un mayor riesgo de mortalidad por COVID-19.
- Las enfermedades preexistentes, incluida la diabetes y el asma grave, aumentaron el riesgo de muerte.
- Los grupos étnicos negros y del sur de Asia mostraron un mayor riesgo de muerte relacionada con el COVID-19 en comparación con las personas blancas, incluso después de ajustar por otros factores.
Conclusiones:
- Cuantificó numerosos factores clínicos relacionados con la mortalidad por COVID-19 en un estudio de cohorte grande.
- Destacó las disparidades étnicas significativas en los resultados de COVID-19.
- Hizo hincapié en la expansión continua de la plataforma OpenSAFELY para la actualización continua de los resultados.
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