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Proteins that regulate transcription can do so either via direct contact with RNA Polymerase or through indirect interactions facilitated by adaptors, mediators, histone-modifying proteins, and nucleosome remodelers. Direct interactions to activate transcription is seen in bacteria as well as in some eukaryotic genes. In these cases, upstream activation sequences are adjacent to the promoters, and the activator proteins interact directly with the transcriptional machinery. For example, in...
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Transcription activators are proteins that promote the transcription of genes from DNA to RNA. In most cases, these proteins contain two separate domains ‒ a domain that binds to DNA and a domain for activating transcription; however, in some cases, a single domain is responsible for both binding and activation of transcription, as seen in the glucocorticoid receptor and MyoD.
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Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
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Video Experimental Relacionado

Updated: Dec 15, 2025

Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models
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Reguladores de la transcripción del virus humano

Xing Liu1, Ted Hong2, Sreeja Parameswaran3

  • 1Biology Department, Boston University, Boston, MA 02215, USA.

Cell
|July 11, 2020
PubMed
Resumen

Este estudio cataloga 419 reguladores virales de transcripción (vTR) de 20 familias de virus, revelando sus objetivos y roles en enfermedades humanas. Este recurso ayuda a la investigación en virología y genómica.

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Área de la Ciencia:

  • Virología
  • La genómica
  • Genética de las enfermedades humanas

Sus antecedentes:

  • Los genomas virales codifican reguladores de transcripción (vTR) que modulan la expresión génica viral y del huésped.
  • En la actualidad, no existe una anotación exhaustiva de los vTR humanos, lo que dificulta la comprensión de sus funciones y la relevancia de la enfermedad.

Objetivo del estudio:

  • Crear un catálogo completo de los reguladores virales de la transcripción humana (vTR).
  • Caracterizar los objetivos celulares y las vías afectadas por los vTR.
  • Esclarecer el papel de los VTR en la patogénesis de las enfermedades humanas.

Principales métodos:

  • Compilación de un catálogo de 419 vTRs de 20 familias de virus distintas.
  • Análisis bioinformático para identificar genes celulares compartidos y únicos, proteínas y vías dirigidas por vTR.

Principales resultados:

  • Se estableció un catálogo de 419 vTR de 20 familias de virus.
  • Se realizó la caracterización de objetivos celulares y vías moduladas por vTRs específicos.
  • Se obtuvieron conocimientos sobre la participación de los vTR en la patogénesis de enfermedades humanas.

Conclusiones:

  • El catálogo desarrollado sirve como un recurso valioso para la virología, la genómica y la genética de las enfermedades humanas.
  • Comprender las vTR es crucial para descifrar los mecanismos virales y su impacto en la salud humana.