Video Experimental Relacionado
Updated: Dec 13, 2025
06:29
Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay
Published on: March 1, 2011
26.8K
Asociación de la inflamación por COVID-19 con la activación del eje C5a-C5aR1
Julien Carvelli1,2, Olivier Demaria3, Frédéric Vély4,5
1Assistance Publique des Hôpitaux de Marseille, Hôpital de la Timone, Réanimation des Urgences, Marseilles, France.
Nature
|July 30, 2020
Resumen
La vía C5a-C5aR1 impulsa la inflamación en el síndrome de dificultad respiratoria aguda por COVID-19. El bloqueo de este eje con anticuerpos redujo la infiltración de células mieloides y la lesión pulmonar en modelos preclínicos.
Área de la Ciencia:
- Inmunología
- Fisiopatología
- Medicina traslacional
Sus antecedentes:
- El COVID-19, causado por el SARS-CoV-2, es una enfermedad pandémica.
- El factor de complemento C5a y su receptor C5aR1 están implicados en las respuestas inflamatorias.
Objetivo del estudio:
- Para investigar el papel del eje C5a-C5aR1 en la gravedad del COVID-19.
- Para evaluar el potencial terapéutico del bloqueo C5aR1.
Principales métodos:
- Análisis longitudinal de las células inmunes y los factores solubles en pacientes con COVID-19.
- Análisis fenotípico de la sangre y el líquido de lavado broncoalveolar.
- Estudios in vitro e in vivo con anticuerpos C5aR1 y ratones knock-in C5aR1.
Principales resultados:
- Los niveles de C5a soluble se correlacionan con la gravedad del COVID-19.
- Se observó una alta expresión de C5aR1 en las células mieloides de los pacientes con COVID-19.
- Los anticuerpos anti-C5aR1 inhiben el reclutamiento y la activación de las células mieloides y reducen la lesión pulmonar aguda en ratones.
Conclusiones:
- El eje C5a-C5aR1 juega un papel crítico en el síndrome de dificultad respiratoria aguda asociado a COVID-19.
- Dirigirse a C5aR1 puede ser una estrategia terapéutica viable para mitigar la inflamación y la lesión pulmonar en COVID-19 grave.
Más Videos Relacionados
Videos de Conceptos Relacionados
01:38Inflammation
60.9K
Overview
60.9K
01:20The JAK-STAT Signaling Pathway
11.3K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
11.3K
01:28Inflammatory Response
15.5K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
15.5K
01:30Inflammatory Response I: Vascular and Cellular
15.3K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
15.3K
01:24T Cell Types and Functions
1.9K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.9K
01:24Inflammatory Response II: Inflammatory Exudate and Tissue Repair
6.8K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
6.8K