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Information enters the brain through encoding, which is the input of information into the memory system. Once sensory information is received from the environment, the brain labels or codes it. The information is then organized with similar information and connected to existing concepts. Encoding occurs through automatic processing and effortful processing.
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The information-processing theory of cognitive development centers on fundamental mental processes, including attention, memory, and problem-solving skills. Researchers in this field examine how cognitive abilities, such as working memory, evolve and influence children's overall development. Studies indicate that children with stronger working memory tend to excel in reading comprehension, math, and problem-solving compared to peers with less efficient memory skills. Low working memory is...
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Information is everywhere and its presentation—such as how and when items are presented—can impact our perceptions and decisions surrounding the info. This broad concept umbrellas framing effects—influences that occur due to the way information is framed in its appearance, whether it’s purely the order or the specific wording of a message. Let’s take a look at numerous ways in which two versions of something can objectively say the same thing, yet we respond in...
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Perspectivas para el ENCODE

, Michael P Snyder1,2, Thomas R Gingeras3

  • 1Department of Genetics, School of Medicine, Stanford University, Palo Alto, CA, USA. mpsnyder@stanford.edu.

Nature
|July 31, 2020
PubMed
Resumen
Este resumen es generado por máquina.

El proyecto de la Enciclopedia de los Elementos del ADN (ENCODE) mapea los genomas humanos y de ratón, identificando elementos funcionales como los elementos cis-reguladores candidatos (cCREs) para la investigación de la regulación génica.

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Área de la Ciencia:

  • La genómica
  • Biología molecular
  • La bioinformática

Sus antecedentes:

  • El Proyecto Enciclopedia de los Elementos del ADN (ENCODE) tiene como objetivo mapear los elementos funcionales en el genoma humano.
  • Los elementos funcionales incluyen genes, regiones reguladoras y isoformas de transcripción.

Objetivo del estudio:

  • Crear un mapa completo de los elementos funcionales en los genomas de humanos y ratones.
  • Identificar los elementos cisreguladores candidatos (cRE) implicados en la regulación de los genes.

Principales métodos:

  • Utilizó datos genómicos para identificar genes, regiones reguladoras y isoformas de transcripción.
  • Técnicas aplicadas para anotar las marcas bioquímicas asociadas con la regulación génica.
  • Ampliado el ámbito de aplicación de ENCODE para incluir organismos modelo, específicamente el ratón.

Principales resultados:

  • Generó casi un millón de anotaciones cCRE para el genoma humano.
  • Generó más de 300.000 anotaciones de cCRE para el genoma del ratón.
  • Estableció un recurso valioso para la comunidad científica en la comprensión de la función del genoma.

Conclusiones:

  • El proyecto ENCODE ha mapeado con éxito numerosos elementos genómicos funcionales.
  • Las anotaciones cCRE generadas proporcionan información crítica sobre la regulación génica.
  • Este recurso ayuda significativamente a la investigación en curso en genómica y biología molecular.