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ROMP-Boranes como catalizadores orgánicos de ácido de Lewis resistentes a la humedad y reciclables
Fernando Vidal1, James McQuade1, Roger Lalancette1
1Department of Chemistry, Rutgers University-Newark, 73 Warren Street, Newark, New Jersey 07102, United States.
Journal of the American Chemical Society
|August 14, 2020
Resumen
En este estudio se introducen catalizadores de ácido de Lewis de arilborano reciclables mediante la polimerización por metástasis de apertura de anillo (ROMP). Estos nuevos polímeros permiten una reducción eficiente de la N-alquilación con bajas cargas de catalizador.
Área de la Ciencia:
- Catálisis
- Química de los polímeros
- Síntesis orgánica
Sus antecedentes:
- Los ácidos de Lewis de arilborano son catalizadores eficaces, pero se enfrentan a limitaciones debido a la complejidad de las síntesis y a las altas exigencias de carga.
- El desarrollo de sistemas catalíticos reciclables y versátiles para los arilboranos sigue siendo un desafío importante en la química orgánica.
Objetivo del estudio:
- Desarrollar una nueva plataforma modular para la creación de catalizadores de ácido de Lewis arilborano reciclables.
- Demostrar la eficacia de estos catalizadores en las reacciones reductoras de N-alquilación.
Principales métodos:
- Se utilizó la polimerización por metástasis de apertura de anillo (ROMP) de fenilnorbornenos funcionalizados con borano.
- Sintetizó copolímeros lineales solubles y organogeles entrelazados.
- Los polímeros resultantes se emplean como catalizadores en la N-alquilación reductora de las arylaminas.
Principales resultados:
- Se logra una catálisis de alta eficiencia con cargas de catalizador excepcionalmente bajas.
- Se ha demostrado un excelente control y tolerancia funcional del grupo.
- Se han desarrollado con éxito catalizadores de polímeros reciclables solubles y reticulados.
Conclusiones:
- El ROMP proporciona un enfoque versátil y modular para el diseño de organocatalizadores con soporte.
- Estos nuevos polímeros ROMP-borano ofrecen una alternativa eficiente y reciclable para la catálisis con ácido de Lewis.
- La metodología es adaptable a varios triarilboranos, ampliando el alcance de la organocatálisis soportada.
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