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Transmisión criptográfica del SARS-CoV-2 en el estado de Washington
Trevor Bedford1,2,3, Alexander L Greninger4,5, Pavitra Roychoudhury4,5
1Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. tbedford@fredhutch.org.
Science (New York, N.Y.)
|September 11, 2020
Resumen
La mayoría de las infecciones por coronavirus 2 del síndrome respiratorio agudo grave (SARS-CoV-2) en el estado de Washington se originaron a partir de un solo evento de introducción. Esta única introducción condujo a una propagación local antes de que comenzara la vigilancia generalizada.
Área de la Ciencia:
- Virología
- Epidemiología
- La genómica
Sus antecedentes:
- El coronavirus 2 del síndrome respiratorio agudo severo (SARS-CoV-2) surgió a fines de 2019 y se extendió por todo el mundo.
- La secuenciación del genoma es crucial para reconstruir el historial de transmisión viral.
- La vigilancia eficaz es clave para controlar los brotes.
Objetivo del estudio:
- Analizar los orígenes y la dinámica de transmisión temprana del SARS-CoV-2 en el estado de Washington.
- Determinar el número de introducciones de SARS-CoV-2 en la región.
- Comprender el impacto de la vigilancia en la contención del brote.
Principales métodos:
- Análisis de 453 genomas de SARS-CoV-2 del estado de Washington.
- Datos genómicos recopilados entre el 20 de febrero y el 15 de marzo de 2020.
- Análisis filogenético para reconstruir el historial de transmisión.
Principales resultados:
- La mayoría de las infecciones por SARS-CoV-2 muestreadas se remontan a un solo evento de introducción.
- La introducción probablemente ocurrió a fines de enero o principios de febrero de 2020.
- El virus se propagó localmente después de esta única introducción antes de la vigilancia activa.
Conclusiones:
- Un solo evento de introducción sembró el brote de SARS-CoV-2 en el estado de Washington.
- La transmisión local temprana ocurrió antes de la implementación de la vigilancia comunitaria activa.
- La epidemiología genómica proporciona información crítica sobre la propagación y los orígenes virales.
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