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La conducción axonal local da forma a las propiedades espaciotemporales de las secuencias neuronales
Robert Egger1, Yevhen Tupikov2, Margot Elmaleh1
1NYU Neuroscience Institute and Department of Otolaryngology, New York University Langone Medical Center, New York, NY 10016, USA; Center for Neural Science, New York University, New York, NY 10003, USA.
Cell
|October 16, 2020
Resumen
Los mecanismos de circuito neuronal para la activación secuencial, cruciales para el canto de cortejo en los pinzones cebra, implican retrasos heterogéneos. Las líneas de retraso axonal locales en la región HVC determinan significativamente los patrones de actividad neuronal.
Área de la Ciencia:
- La neurociencia
- Neurociencia computacional
- El comportamiento de los animales
Sus antecedentes:
- La activación neuronal secuencial subyace a comportamientos complejos, pero los mecanismos del circuito no están claros.
- La región HVC en los pinzones cebra es vital para el control temporal preciso en la canción de cortejo.
Objetivo del estudio:
- Investigar las secuencias premotoras en la región HVC de los pinzones cebra adultos.
- Comprender los mecanismos de circuito que dan forma a la actividad neuronal durante la producción de canciones.
Principales métodos:
- Utilizó sondas de silicio de alta densidad para registrar la actividad de la población en HVC.
- Comparó los datos experimentales con las predicciones de varios modelos de red.
Principales resultados:
- Identificó una arquitectura de circuito donde los retrasos heterogéneos entre las neuronas dan forma a la actividad.
- Se encontró que la conducción lenta a través de colaterales axonales locales dentro de HVC es una fuente de retraso primaria (1-7.5 ms por enlace).
Conclusiones:
- Las líneas de retraso axonal locales son críticas para el repertorio dinámico de los circuitos neuronales.
- Estos retrasos contribuyen significativamente a la precisión temporal requerida para la canción de cortejo.
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