Video Experimental Relacionado

Updated: Dec 4, 2025

Single-Cell Factor Localization on Chromatin using Ultra-Low Input Cleavage Under Targets and Release using Nuclease
09:20

Single-Cell Factor Localization on Chromatin using Ultra-Low Input Cleavage Under Targets and Release using Nuclease

Published on: February 1, 2022

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Potencial de cromatina identificado por perfilado compartido de una sola célula de ARN y cromatina

Sai Ma1, Bing Zhang2, Lindsay M LaFave3

  • 1Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biology and Koch Institute, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.

Cell
|October 25, 2020
PubMed
Resumen

Desarrollamos SHARE-seq, un método para medir la accesibilidad de la cromatina y la expresión génica en células individuales. Esta técnica revela cómo los cambios de cromatina preceden las decisiones del destino celular, ayudando a comprender la diferenciación celular.

Palabras clave:
La epigenomíaregulación genéticade una sola celdala pielcélula madre

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