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Características físicas del cáncer
Hadi T Nia1,2, Lance L Munn1, Rakesh K Jain3,4
1Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Science (New York, N.Y.)
|October 30, 2020
Resumen
El microambiente físico tiene un impacto significativo en la progresión del tumor y la resistencia al tratamiento. Comprender los rasgos físicos como el estrés, la presión, la rigidez y la microarquitectura ofrece nuevas estrategias terapéuticas para el cáncer.
Área de la Ciencia:
- Biología del cáncer
- La biofísica
- Oncología traslacional
Sus antecedentes:
- El papel del microambiente físico en el cáncer es cada vez más reconocido.
- Un enfoque multidisciplinario que involucra a ingenieros, físicos y biólogos está avanzando en la investigación del cáncer.
- Las ciencias físicas de los descubrimientos del cáncer están llevando a nuevas estrategias terapéuticas.
Objetivo del estudio:
- Revisar los rasgos físicos de los tumores que impulsan la progresión y la resistencia al tratamiento.
- Para definir y discutir las causas y consecuencias de estos rasgos físicos.
- Para integrar los rasgos físicos con las características biológicas establecidas del cáncer.
Principales métodos:
- Revisión de la literatura de las ciencias físicas del cáncer.
- Análisis de los parámetros físicos, incluidas las tensiones sólidas, la presión intersticial del fluido, las propiedades del material (rigidez) y la microarquitectura.
- Discusión de la interacción entre los rasgos físicos y las características biológicas.
Principales resultados:
- Se identificaron cuatro rasgos físicos clave: tensiones sólidas elevadas, presión de fluido intersticial elevada, propiedades de material alteradas (por ejemplo, rigidez) y microarquitectura física alterada.
- Estas características físicas contribuyen a la progresión del tumor y a la resistencia al tratamiento.
- Los rasgos físicos complementan y proporcionan un marco para la comprensión de las características biológicas.
Conclusiones:
- Las propiedades físicas del microambiente tumoral son determinantes críticos de la progresión del cáncer y la respuesta terapéutica.
- Dirigirse a estos rasgos físicos presenta una vía prometedora para desarrollar nuevas terapias contra el cáncer.
- La integración de las perspectivas físicas y biológicas ofrece una comprensión más completa del cáncer.
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