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Multi-Omics resuelve un cambio agudo en el estado de la enfermedad entre COVID-19 leve y moderado
Yapeng Su1, Daniel Chen1, Dan Yuan2
1Institute for Systems Biology, Seattle, WA 98109, USA.
Cell
|November 10, 2020
Resumen
Los investigadores analizaron los datos clínicos, las células inmunes y los multiómicos plasmáticos en 139 pacientes con COVID-19. La enfermedad moderada muestra cambios metabólicos e inmunológicos significativos, lo que sugiere que
Área de la Ciencia:
- Inmunología
- Metabolomía
- Investigación sobre el COVID-19
Sus antecedentes:
- El COVID-19 presenta un amplio espectro de gravedad de la enfermedad.
- Comprender los cambios sistémicos tempranos en el COVID-19 es crucial para un tratamiento efectivo.
Objetivo del estudio:
- Investigar los perfiles clínicos, inmunológicos y metabólicos integrados de los pacientes con COVID-19 a través de la gravedad de la enfermedad.
- Identificar los puntos clave de transición y los factores biológicos de la progresión de la enfermedad.
Principales métodos:
- Análisis integrado de datos clínicos, fenotipos de células inmunes y multi-ómicos de plasma de 139 pacientes con COVID-19.
- Serial toma de sangre durante la primera semana después del diagnóstico.
- Reducción de la dimensión de más de 120.000 características inmunes en un solo eje de respuesta.
Principales resultados:
- Se produce un cambio significativo en los metabolitos plasmáticos y los procesos metabólicos entre la COVID-19 leve y moderada.
- Aparición y amplificación de fenotipos inusuales de células inmunes en la enfermedad de moderada a grave.
- Un "eje de respuesta inmune" se correlaciona con los cambios en el plasma, la coagulación de la sangre y la transición de la gravedad de la enfermedad.
Conclusiones:
- El COVID-19 moderado representa una coyuntura crítica con alteraciones metabólicas e inmunológicas distintas.
- El eje de respuesta inmune identificado proporciona una visión unificada de la respuesta del huésped al SARS-CoV-2.
- Las intervenciones terapéuticas durante la etapa moderada de la enfermedad pueden ser más efectivas.
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