Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Genomics02:02

Genomics

39.0K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
39.0K
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

17.5K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
17.5K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

2.9K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
2.9K
Proteomics01:33

Proteomics

9.0K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
9.0K
Factors Affecting Illness01:18

Factors Affecting Illness

4.8K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
4.8K
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

111
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
111

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Characterization of Ground-Based Particle Emissions from an Airbus A350-900 Operating on Conventional and Sustainable Fuels as Part of the ECLIF3 Campaign.

Environmental science & technology·2026
Same author

Physical activity promotion in Spanish adults with spinal cord injury: community guidelines, supporting resources and messaging strategies.

Disability and rehabilitation·2025
Same author

Author Correction: CD8<sup>+</sup> T cells induce cachexia during chronic viral infection.

Nature immunology·2025
Same author

Design and validation of a clinical whole genome sequencing-based assay for patient screening in a large healthcare system.

Frontiers in molecular biosciences·2025
Same author

Quality participation of physical activity matters for quality of life and subjective wellbeing in people with disabilities.

Psychology of sport and exercise·2025
Same author

Early and opposing neutrophil and CD4 T cell responses shape pulmonary tuberculosis pathology.

The Journal of experimental medicine·2025

Video Experimental Relacionado

Updated: Dec 1, 2025

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.8K

Multi-Omics resuelve un cambio agudo en el estado de la enfermedad entre COVID-19 leve y moderado

Yapeng Su1, Daniel Chen1, Dan Yuan2

  • 1Institute for Systems Biology, Seattle, WA 98109, USA.

Cell
|November 10, 2020
PubMed
Resumen

Los investigadores analizaron los datos clínicos, las células inmunes y los multiómicos plasmáticos en 139 pacientes con COVID-19. La enfermedad moderada muestra cambios metabólicos e inmunológicos significativos, lo que sugiere que

Palabras clave:
CITE-secuenciaEl COVID-19respuesta inmuneInfecciónMetabolomíamultiómicaProteomíaADN de una sola célulaTCR-seq de una sola célulaSecreto de una sola célula

Más Videos Relacionados

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19
08:48

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Published on: February 16, 2022

3.2K
Author Spotlight: Advancing Alzheimer's Research &#8211; Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

1.5K

Videos de Experimentos Relacionados

Last Updated: Dec 1, 2025

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.8K
Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19
08:48

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Published on: February 16, 2022

3.2K
Author Spotlight: Advancing Alzheimer's Research &#8211; Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

1.5K

Área de la Ciencia:

  • Inmunología
  • Metabolomía
  • Investigación sobre el COVID-19

Sus antecedentes:

  • El COVID-19 presenta un amplio espectro de gravedad de la enfermedad.
  • Comprender los cambios sistémicos tempranos en el COVID-19 es crucial para un tratamiento efectivo.

Objetivo del estudio:

  • Investigar los perfiles clínicos, inmunológicos y metabólicos integrados de los pacientes con COVID-19 a través de la gravedad de la enfermedad.
  • Identificar los puntos clave de transición y los factores biológicos de la progresión de la enfermedad.

Principales métodos:

  • Análisis integrado de datos clínicos, fenotipos de células inmunes y multi-ómicos de plasma de 139 pacientes con COVID-19.
  • Serial toma de sangre durante la primera semana después del diagnóstico.
  • Reducción de la dimensión de más de 120.000 características inmunes en un solo eje de respuesta.

Principales resultados:

  • Se produce un cambio significativo en los metabolitos plasmáticos y los procesos metabólicos entre la COVID-19 leve y moderada.
  • Aparición y amplificación de fenotipos inusuales de células inmunes en la enfermedad de moderada a grave.
  • Un "eje de respuesta inmune" se correlaciona con los cambios en el plasma, la coagulación de la sangre y la transición de la gravedad de la enfermedad.

Conclusiones:

  • El COVID-19 moderado representa una coyuntura crítica con alteraciones metabólicas e inmunológicas distintas.
  • El eje de respuesta inmune identificado proporciona una visión unificada de la respuesta del huésped al SARS-CoV-2.
  • Las intervenciones terapéuticas durante la etapa moderada de la enfermedad pueden ser más efectivas.