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Tres cuartas partes de la tasa de ataque de SARS-CoV-2 en la Amazonía brasileña durante una epidemia en gran medida
Lewis F Buss1, Carlos A Prete2, Claudia M M Abrahim3
1Departamento de Molestias Infecciosas e Parasitarias and Instituto de Medicina Tropical da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Science (New York, N.Y.)
|December 9, 2020
Resumen
La tasa de ataques de COVID-19 en Manaus, Brasil, alcanzó el 76% en octubre de 2020, lo que indica una epidemia generalizada y no mitigada. Esta alta tasa de infección subraya el severo impacto de la propagación de la enfermedad por coronavirus 2019 mal controlada.
Área de la Ciencia:
- Epidemiología
- Inmunología
Sus antecedentes:
- El coronavirus 2 del síndrome respiratorio agudo severo (SARS-CoV-2) causó una rápida epidemia en Manaus, en el norte de Brasil.
- La epidemia en Manaus no se mitigó en gran medida, lo que requirió una estimación de su tamaño final.
Objetivo del estudio:
- Para estimar la tasa de ataques de COVID-19 en Manaus, Brasil, utilizando datos serológicos.
- Para comparar la tasa de ataques en Manaus con la de São Paulo.
Principales métodos:
- Se utilizó una muestra de conveniencia de donantes de sangre para detectar anticuerpos de inmunoglobulina G (IgG).
- Se aplicaron correcciones estadísticas para respuestas de anticuerpos no detectables y disminución de anticuerpos.
Principales resultados:
- En junio de 2020, el 44% de la población de Manaus tenía anticuerpos IgG detectables.
- La tasa estimada de ataques de COVID-19 en Manaus fue del 66% en junio, aumentando al 76% en octubre.
- La tasa estimada de ataques en São Paulo fue del 29% en octubre.
Conclusiones:
- El COVID-19 no controlado puede infectar a una parte sustancial de la población.
- Manaus experimentó una tasa de ataque significativamente más alta en comparación con São Paulo.
- Las altas tasas de ataques están asociadas con una mortalidad significativa.
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