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Los condensados de proteínas como fluidos de Maxwell de envejecimiento
Louise Jawerth1,2, Elisabeth Fischer-Friedrich3,4, Suropriya Saha1
1Max Planck Institute for the Physics of Complex Systems, Nöthnitzer Str. 38, 01187 Dresden, Germany.
Science (New York, N.Y.)
|December 11, 2020
Resumen
Los condensados de proteínas actúan como gafas de Maxwell, exhibiendo propiedades viscoelásticas dependientes del tiempo. Su viscosidad aumenta con la edad, ofreciendo información sobre la modulación bioquímica celular.
Área de la Ciencia:
- La biofísica
- Física de la materia blanda
- Biología celular
Sus antecedentes:
- Los condensados de proteínas son fluidos complejos con propiedades materiales dinámicas.
- Actualmente no existe una descripción reológica completa de estos fluidos.
Objetivo del estudio:
- Caracterizar las propiedades reológicas dependientes del tiempo de los condensados de proteínas in vitro.
- Establecer un modelo reológico adecuado para los condensados de proteínas.
Principales métodos:
- Utilizó una pinza láser de reología activa.
- Reología pasiva basada en microperlas para la caracterización.
- Los cambios estructurales analizados mediante microscopía electrónica.
Principales resultados:
- Los condensados de proteínas exhiben un comportamiento de fluido Maxwell viscoelástico a través de diferentes edades.
- La viscosidad aumenta significativamente con la edad del condensado.
- El módulo elástico muestra una variación mínima con la edad, sin cambios estructurales significativos observados.
Conclusiones:
- Los condensados de proteínas funcionan como materiales vidriosos suaves, llamados vidrios de Maxwell.
- Estos materiales poseen propiedades dependientes de la edad cruciales para la modulación bioquímica celular.
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