Video Experimental Relacionado

Updated: Nov 23, 2025

Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms
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Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms

Published on: January 25, 2018

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Bases estructurales de la inhibición y modulación de la γ-secretasa por fármacos de pequeñas moléculas

Guanghui Yang1, Rui Zhou2, Xuefei Guo2

  • 1Beijing Advanced Innovation Center for Structural Biology and Research Center for Biological Structure, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China; State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, China.

Cell
|December 29, 2020
PubMed
Resumen

Las ideas estructurales sobre los inhibidores de la γ-secretasa (GSIs) y los moduladores (GSM) revelan cómo se dirigen a las vías de la enfermedad de Alzheimer y el cáncer. Comprender estos mecanismos es clave para desarrollar terapias de próxima generación.

Palabras clave:
Crio-EMlas drogasel inhibidorModulador de energíaLa estructuraSecretaza γ

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