Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.6K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.6K
Cancer Therapies02:49

Cancer Therapies

9.1K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.1K
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

5.3K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
5.3K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.1K
Cancer02:18

Cancer

52.2K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
52.2K
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.3K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.3K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Circadian Controlled Transcription in Brain and Peripheral Organs of Juvenile and Adult Mice.

International journal of molecular sciences·2026
Same author

Intravitreal photoswitch therapy in advanced retinitis pigmentosa: a phase 1 open-label trial.

Nature medicine·2026
Same author

Combinatorial treatment of glioblastoma with temozolomide (TMZ) plus 5-ethynyl-2'-deoxyuridine (EdU).

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Combinatorial Treatment of Glioblastoma with Temozolomide (TMZ) Plus 5-Ethynyl-2'-deoxyuridine (EdU).

bioRxiv : the preprint server for biology·2025
Same author

Genome-wide strand-specific UV mutagenesis in <i><i>Escherichia coli</i></i> is directed by the Mfd translocase.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Chromatin context shapes DNA damage formation and nucleotide excision repair dynamics in Caenorhabditis elegans.

Nucleic acids research·2025

Video Experimental Relacionado

Updated: Nov 23, 2025

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
11:56

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

10.1K

Relojes, cáncer y cronoquimioterapia

Aziz Sancar1, Russell N Van Gelder2

  • 1Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA. aziz_sancar@med.unc.edu russvg@uw.edu.

Science (New York, N.Y.)
|January 1, 2021
PubMed
Resumen

El reloj circadiano humano influye en las funciones corporales, pero su vínculo directo con el desarrollo del cáncer sigue sin probarse. La investigación sugiere potencial en el tiempo de tratamiento del cáncer, pero se necesitan más estudios.

Más Videos Relacionados

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics
06:00

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics

Published on: May 14, 2016

11.3K
Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.6K

Videos de Experimentos Relacionados

Last Updated: Nov 23, 2025

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
11:56

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

10.1K
Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics
06:00

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics

Published on: May 14, 2016

11.3K
Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.6K

Área de la Ciencia:

  • Cronología
  • En el campo de la oncología
  • Biología molecular

Sus antecedentes:

  • El reloj circadiano regula los procesos fisiológicos y de comportamiento esenciales.
  • Se supone que la disfunción del reloj contribuye al desarrollo del cáncer.
  • La evidencia que vincula el trastorno circadiano con el cáncer es sugerente pero no concluyente.

Objetivo del estudio:

  • Para revisar la evidencia del papel del reloj circadiano en el cáncer.
  • Evaluar el potencial de la cronoquimioterapia en el tratamiento del cáncer.

Principales métodos:

  • Revisión de los estudios epidemiológicos.
  • Análisis de los datos de los modelos animales.
  • Evaluación de los resultados de los ensayos clínicos de cronoquimioterapia.

Principales resultados:

  • Los estudios epidemiológicos y en animales sugieren una relación entre el trastorno circadiano y el cáncer.
  • Los ensayos clínicos aún no han mostrado mejores resultados para la cronoquimioterapia.
  • El tiempo circadiano puede influir en la eficacia de la quimioterapia, pero esto requiere más investigación.

Conclusiones:

  • Los datos actuales son insuficientes para establecer la interrupción del reloj como un factor carcinogénico general.
  • La cronoquimioterapia aún no ha demostrado resultados superiores a los regímenes convencionales.
  • Se necesitan más investigaciones para explorar las interacciones específicas del reloj con el cáncer para aplicaciones clínicas.