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La transvección regula la expresión sesgada por sexo de un gen ligado al X de la mosca

Charalampos Chrysovalantis Galouzis¹, Benjamin Prud'homme²

¹Aix-Marseille Université, CNRS, Institut de Biologie du Développement de Marseille (IBDM), Campus de Luminy Case 907, 13288 Marseille Cedex 9, France.

Science (New York, N.Y.)

|January 22, 2021

Resumen

La expresión génica sesgada por sexo en Drosophila biarmipes no está determinada únicamente por las jerarquías sexuales. La transvección, una interacción reguladora, silencia un potenciador genético clave en las hembras, lo que lleva a patrones de alas sesgadas por los machos.

Área de la Ciencia:

La genética
Biología del desarrollo
Biología evolutiva

Sus antecedentes:

El dimorfismo sexual surge de la expresión genética sesgada por el sexo.
Las jerarquías genéticas de determinación del sexo controlan estos patrones de expresión.
El gen amarillo en el cromosoma X muestra expresión de ala sesgada masculina en Drosophila biarmipes.

Objetivo del estudio:

Investigar los mecanismos reguladores que subyacen a la expresión del gen amarillo sesgado por el macho.
Determinar si este patrón está controlado por la jerarquía de determinación del sexo u otros factores.

Principales métodos:

Análisis del patrón de expresión del gen amarillo en Drosophila biarmipes.
Investigando el papel de la transvección en la regulación génica.
Examinando la participación del intrón amarillo y la proteína Mod (mdg4).

Principales resultados:

La expresión del ala masculina de amarillo es independiente de la jerarquía de determinación del sexo.
La transvección silencia un potenciador amarillo en las hembras (XX) pero no en los machos (XY).
Este silenciamiento requiere el intrón amarillo y la proteína Mod ((mdg4).

Conclusiones:

La transvección es un mecanismo clave que impulsa la expresión génica sesgada por sexo en Drosophila.
Este proceso contribuye al dimorfismo sexual mediante la regulación de los genes vinculados a X.
Los hallazgos sugieren que la transvección puede influir ampliamente en la expresión sesgada por sexo de los genes vinculados a X.

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