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Expansión masiva de la diversidad de bacteriófagos intestinales humanos
Luis F Camarillo-Guerrero1, Alexandre Almeida2, Guillermo Rangel-Pineros3
1Host-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.
Cell
|February 19, 2021
Resumen
Los científicos crearon una base de datos de fagos intestinales con ~ 142,000 genomas virales de metagenomas intestinales humanos. Esto revela una amplia diversidad viral y redes de flujo genético, mejorando la investigación futura del viroma.
Área de la Ciencia:
- Microbiología
- Virología
- La genómica
Sus antecedentes:
- Los bacteriófagos son cruciales para la evolución y adaptación bacteriana.
- La diversidad y la prevalencia de los virus en el microbioma intestinal humano no se comprenden bien.
Objetivo del estudio:
- Para catalogar la diversidad viral en el intestino humano.
- Para investigar las interacciones entre fagos y huéspedes y el flujo de genes.
- Establecer un recurso completo para la investigación del virus intestinal.
Principales métodos:
- Minería de datos metagenómicos de 28.060 muestras de intestino humano.
- El ensamblaje y la desredundancia de los genomas virales (> 10 kb).
- Asignación de huéspedes y análisis filogenético de grupos virales (VC).
Principales resultados:
- Generó la base de datos de fagos intestinales con ~ 142,000 genomas virales no redundantes.
- Identificó la mayor diversidad viral dentro del filo Firmicutes.
- ~36% de los grupos virales facilitan el flujo genético entre especies bacterianas.
- Descubrió 280 VC distribuidos globalmente y un clado de fagos prevalente.
Conclusiones:
- El intestino humano alberga poblaciones de bacteriófagos extensas y diversas.
- Los bacteriófagos forman complejas redes de flujo génico que influyen en la evolución bacteriana.
- La base de datos de fagos intestinales es un recurso valioso para estudiar los viromas intestinales y la ecología de los fagos.
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