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Sulfur is an essential element in biological systems, contributing to synthesizing key biomolecules, including amino acids such as cysteine and methionine, and cofactors such as coenzyme A and biotin. Microorganisms primarily assimilate sulfur as sulfate (SO₄²⁻) from the environment, which must undergo a series of biochemical transformations before it can be incorporated into cellular components. As sulfate is highly oxidized, it must undergo assimilatory sulfate reduction to...
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Updated: Nov 16, 2025

Prospecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation
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El secuestro de azufre promueve la multicelularidad durante la limitación de nutrientes

Beth Kelly1, Gustavo E Carrizo1, Joy Edwards-Hicks1

  • 1Max Planck Institute for Immunobiology and Epigenetics, Freiburg, Germany.

Nature
|February 25, 2021
PubMed
Resumen

La limitación de nutrientes en Dictyostelium discoideum desencadena especies reactivas de oxígeno, que secuestran la cisteína en el glutatión. Esta regulación del azufre detiene la proliferación, permitiendo el desarrollo multicelular y destacando el oxígeno y el azufre

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Área de la Ciencia:

  • Biología celular
  • La bioquímica
  • Biología del desarrollo

Sus antecedentes:

  • Dictyostelium discoideum exhibe cambios de comportamiento dependientes de los nutrientes, pasando de estados unicelulares a multicelulares después de la inanición.
  • Este organismo sirve como modelo para comprender cómo el metabolismo influye en la diferenciación y la función celular.

Objetivo del estudio:

  • Investigar el papel de las especies reactivas del oxígeno (ROS) en el Dictyostelium discoideum, limitado en nutrientes.
  • Aclarar el mecanismo por el cual el metabolismo del azufre regula el destino y el desarrollo celular en respuesta a la disponibilidad de nutrientes.

Principales métodos:

  • Análisis de la producción de especies reactivas de oxígeno bajo limitación de nutrientes.
  • Cuantificación del secuestro de cisteína en el glutatión.
  • Evaluación de la utilización de azufre en la traducción de proteínas y la actividad de las enzimas del grupo de hierro-azufre.

Principales resultados:

  • La limitación de nutrientes induce la ROS, lo que lleva al secuestro de cisteína en el glutatión.
  • Este secuestro limita la disponibilidad de azufre para el metabolismo mitocondrial y la proliferación celular.
  • La regulación del azufre por ROS mantiene un estado de no proliferación, facilitando el desarrollo multicelular.

Conclusiones:

  • Las especies reactivas de oxígeno actúan como moléculas de señalización, mediando las decisiones del destino celular a través de la regulación del azufre.
  • El oxígeno y el azufre se identifican como moléculas clave de señalización que dictan el destino celular en los primeros eucariotas.
  • Los hallazgos tienen implicaciones para la comprensión de las respuestas celulares a las fluctuaciones de nutrientes en organismos multicelulares.