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La clofazimina inhibe ampliamente los coronavirus, incluido el SARS-CoV-2

Shuofeng Yuan^1,2,3, Xin Yin^4,5, Xiangzhi Meng²

¹State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.

|March 17, 2021

Resumen

El medicamento contra la lepra clofazimina es prometedor en la lucha contra los coronavirus como el SARS-CoV-2 y el MERS-CoV. Reduce efectivamente la replicación viral y la inflamación, ofreciendo un nuevo tratamiento potencial para el COVID-19 y futuros brotes de coronavirus.

Área de la Ciencia:

Virología
Enfermedades infecciosas
Farmacología

Sus antecedentes:

Los coronavirus, incluidos el SARS-CoV-2, el SARS y el MERS, representan amenazas significativas para la salud mundial.
Existen opciones de tratamiento efectivas limitadas para las infecciones por coronavirus.
Los brotes de coronavirus zoonóticos han ocurrido varias veces en este siglo.

Objetivo del estudio:

Para investigar la actividad antiviral de la clofazimina contra los coronavirus.
Evaluar la eficacia de la clofazimina en modelos preclínicos de la infección por el SARS-CoV-2.
Para explorar el potencial de la clofazimina como agente terapéutico para el COVID-19.

Principales métodos:

Pruebas in vitro de clofazimina contra la replicación del SARS-CoV-2 y el MERS-CoV.
Evaluación del efecto de la clofazimina en la fusión celular mediada por la glicoproteína viral y la actividad de la helicasa.
Estudios in vivo utilizando un modelo de hamster de la infección por SARS-CoV-2 para evaluar la carga viral, el derramamiento y la inflamación.
Estudios de tratamiento combinado con remdesivir.

Principales resultados:

La clofazimina ha demostrado actividad inhibidora contra múltiples coronavirus in vitro.
El medicamento redujo las cargas virales y el derramamiento en los hámsteres infectados por SARS-CoV-2.
La clofazimina alivió la inflamación asociada con la infección por SARS-CoV-2.
Se observaron efectos antivirales sinérgicos cuando se combinó clofazimina con remdesivir.

Conclusiones:

La clofazimina es un candidato prometedor para el tratamiento del COVID-19 y las futuras enfermedades por coronavirus.
Su perfil de seguridad favorable, biodisponibilidad oral y bajo costo lo convierten en una opción atractiva.
La terapia combinada con remdesivir puede mejorar la eficacia del tratamiento en pacientes hospitalizados.

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