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Las vacunas de ARN de mensajería contra el SARS-CoV-2
1Scripps Research, La Jolla, CA, USA.
Cell
|March 19, 2021
Resumen
Las dos primeras vacunas de ARN mensajero (ARNm) demostraron una eficacia y seguridad del 95% en la prevención de la enfermedad por COVID-19. En un ensayo clínico a gran escala, estas vacunas se administraron en forma de dos inyecciones intramusculares con un intervalo de 3 a 4 semanas.
Área de la Ciencia:
- Vacunas y vacunas
- Inmunología
- Enfermedades infecciosas
Sus antecedentes:
- La pandemia de COVID-19 requirió el desarrollo rápido de vacunas efectivas.
- La tecnología de vacunas de ARN mensajero (ARNm) surgió como una plataforma prometedora.
Objetivo del estudio:
- Evaluar la eficacia y seguridad de las dos primeras vacunas de ARNm contra la COVID-19.
- Para evaluar la eficacia de un esquema de vacunación de dos dosis.
Principales métodos:
- Se realizó un ensayo clínico a gran escala en el que participaron 74.000 personas.
- Los participantes recibieron la vacuna de ARNm o un placebo.
- La administración de la vacuna consistió en dos inyecciones intramusculares con un intervalo de 3 a 4 semanas.
Principales resultados:
- Las vacunas de ARNm alcanzaron un 95% de eficacia en la prevención de la enfermedad por COVID-19.
- En el ensayo también se demostró el perfil de seguridad de las vacunas.
- Se observó una alta eficacia después del régimen de dos dosis.
Conclusiones:
- Las dos primeras vacunas de ARNm son altamente efectivas y seguras para inhibir el COVID-19.
- Un esquema de dos dosis intramusculares es una estrategia efectiva para la prevención del COVID-19.
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